Sequence 1: | NP_001356890.1 | Gene: | 5-HT1A / 37196 | FlyBaseID: | FBgn0004168 | Length: | 846 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_032334.2 | Gene: | Htr1a / 15550 | MGIID: | 96273 | Length: | 421 | Species: | Mus musculus |
Alignment Length: | 636 | Identity: | 185/636 - (29%) |
---|---|---|---|
Similarity: | 259/636 - (40%) | Gaps: | 262/636 - (41%) |
- Green bases have known domain annotations that are detailed below.
Fly 203 NGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVAS 267
Fly 268 LAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-I 331
Fly 332 DYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFY 396
Fly 397 VPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTA---- 457
Fly 458 --KSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIA 520
Fly 521 TVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTAT 585
Fly 586 SAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGG----ASTSNATTITSI 646
Fly 647 SALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPH 711
Fly 712 QQAHQQQQQQQQLSSIANPMQKVNKRKETLEAK------RERKAAKTLAIITGAFVVCWLPFFVM 770
Fly 771 ALTMPLC-AACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
5-HT1A | NP_001356890.1 | 7tmA_5-HT1A_invertebrates | 227..>413 | CDD:320454 | 88/186 (47%) |
TM helix 1 | 228..254 | CDD:320454 | 12/25 (48%) | ||
TM helix 2 | 261..287 | CDD:320454 | 15/25 (60%) | ||
TM helix 3 | 299..329 | CDD:320454 | 21/29 (72%) | ||
TM helix 4 | 340..362 | CDD:320454 | 5/21 (24%) | ||
TM helix 5 | 383..412 | CDD:320454 | 12/28 (43%) | ||
7tm_GPCRs | <743..816 | CDD:355774 | 38/79 (48%) | ||
TM helix 6 | 747..772 | CDD:341315 | 15/24 (63%) | ||
TM helix 7 | 784..809 | CDD:341315 | 12/24 (50%) | ||
Htr1a | NP_032334.2 | 7tm_4 | 48..>169 | CDD:304433 | 62/120 (52%) |
7tm_1 | 53..400 | CDD:278431 | 164/579 (28%) | ||
Agonist binding. /evidence=ECO:0000250 | 112..121 | 4/8 (50%) | |||
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 133..135 | 1/1 (100%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 237..268 | 13/67 (19%) | |||
Agonist binding. /evidence=ECO:0000250 | 358..362 | 3/3 (100%) | |||
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 396..400 | 3/3 (100%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E33208_3BCYC | |
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 1 | 1.000 | - | - | H20148 | |
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S4767 |
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D310620at33208 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0002041 | |
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_104614 | |
Panther | 1 | 1.100 | - | - | O | PTHR24247 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X366 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
10 | 9.770 |