DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Htr1a

DIOPT Version :9

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_032334.2 Gene:Htr1a / 15550 MGIID:96273 Length:421 Species:Mus musculus


Alignment Length:636 Identity:185/636 - (29%)
Similarity:259/636 - (40%) Gaps:262/636 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 NGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVAS 267
            |.||..|||.|           ...:||:|||.:|...::||..|:|||.|||:||||||||:.|
Mouse    24 NDTGLSNVTFS-----------YQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGS 77

  Fly   268 LAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-I 331
            |||.||.|:.||:|:.|:|::...|.||...||::.:.||||||:|||||.|||:|||||:|: |
Mouse    78 LAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPI 142

  Fly   332 DYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFY 396
            ||::.||..|...:|...|....::|:.|..||:.|:  .|....:|.:|:|..|.:::|...||
Mouse   143 DYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPE--DRSNPNECTISKDHGYTIYSTFGAFY 205

  Fly   397 VPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTA---- 457
            :|||::|.||.:|::.||.|| |:..:.|:..        ||.|.            |.|:    
Mouse   206 IPLLLMLVLYGRIFRAARFRI-RKTVKKVEKK--------GAGTS------------FGTSSAPP 249

  Fly   458 --KSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIA 520
              ||..|.      |.||                   |...|:.|     || |..|..:|    
Mouse   250 PKKSLNGQ------PGSG-------------------DCRRSAEN-----RA-VGTPCANG---- 279

  Fly   521 TVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTAT 585
                    |.:||                   |||                            ||
Mouse   280 --------AVRQG-------------------EDD----------------------------AT 289

  Fly   586 SAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGG----ASTSNATTITSI 646
                               :||:|..::                |...|    .|.|.||:..  
Mouse   290 -------------------LEVIEVHRV----------------GNSKGHLPLPSESGATSYV-- 317

  Fly   647 SALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPH 711
                                                 |.|                         
Mouse   318 -------------------------------------PAC------------------------- 320

  Fly   712 QQAHQQQQQQQQLSSIANPMQKVNKRKETLEAK------RERKAAKTLAIITGAFVVCWLPFFVM 770
                               :::.|:|  |.|||      ||||..|||.||.|.|::||||||::
Mouse   321 -------------------LERKNER--TAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIV 364

  Fly   771 ALTMPLC-AACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ||.:|.| ::|.:.:.:.::..||||.||.||||||..|:.:|:.|||:|:
Mouse   365 ALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 88/186 (47%)
TM helix 1 228..254 CDD:320454 12/25 (48%)
TM helix 2 261..287 CDD:320454 15/25 (60%)
TM helix 3 299..329 CDD:320454 21/29 (72%)
TM helix 4 340..362 CDD:320454 5/21 (24%)
TM helix 5 383..412 CDD:320454 12/28 (43%)
7tm_GPCRs <743..816 CDD:355774 38/79 (48%)
TM helix 6 747..772 CDD:341315 15/24 (63%)
TM helix 7 784..809 CDD:341315 12/24 (50%)
Htr1aNP_032334.2 7tm_4 48..>169 CDD:304433 62/120 (52%)
7tm_1 53..400 CDD:278431 164/579 (28%)
Agonist binding. /evidence=ECO:0000250 112..121 4/8 (50%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 133..135 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..268 13/67 (19%)
Agonist binding. /evidence=ECO:0000250 358..362 3/3 (100%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 396..400 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BCYC
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20148
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4767
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D310620at33208
OrthoFinder 1 1.000 - - FOG0002041
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_104614
Panther 1 1.100 - - O PTHR24247
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X366
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.770

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