Protein Alignment 5-HT1A and Hrh2

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001399939.1
• Gene: Hrh2 / 15466
• MGIID: 108482
• Length: 421
• Species: Mus musculus
• Alignment Length: 600
• Identity: 110/600 - (18%)
• Similarity: 174/600 - (28%)
• Gaps: 317/600 - (52%)

  Fly   224 LRMAVT-SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYE 287
            :.:.|| ||:|..:|.:|:.|||.|..|:.|.|.|:::.|..:.|||..||.:..||||..|:|:
Mouse    15 IALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQ 79

  Fly   288 ISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWT 351
            :|..|..|...|:|:||.||:.||||||:|..|::|||.|||: :.|....|..||.:.:..:|.
Mouse    80 LSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWV 144

  Fly   352 AAVIVS-LAPQFGWKDPDYLQ-RIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTAR 414
            .::.:| |:...||...:..: ..:..||.|..:..|.:.....|||:|||::...|::|::.||
Mouse   145 ISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAR 209

  Fly   415 KRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGL 479
            ::..|
Mouse   210 EQAKR------------------------------------------------------------ 214

  Fly   480 VDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVN 544
                                                      ::|:
Mouse   215 ------------------------------------------INHI------------------- 218

  Fly   545 GMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLE 609
                                                                             
Mouse   219 ----------------------------------------------------------------- 218

  Fly   610 DPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTS 674
                                      |:..|.||
Mouse   219 --------------------------SSWKAATI------------------------------- 226

  Fly   675 TLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKE 739
                                                                             
Mouse   227 ----------------------------------------------------------------- 226

  Fly   740 TLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVI 804
                 ||.||..|||.:.|||:|||.|:|...:...|.....:::.|..:.|||||.||.|||::
Mouse   227 -----REHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPIL 286

  Fly   805 YTIFSPEFRQAFKRI 819
            |...:.:||.|::::
Mouse   287 YATLNRDFRMAYQQL 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	71/189 (38%)
		TM helix 1	228..254	CDD:320454	12/26 (46%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	5/22 (23%)
		TM helix 5	383..412	CDD:320454	9/28 (32%)
		7tm_GPCRs	<743..816	CDD:475119	30/72 (42%)
		TM helix 6	750..772	CDD:410628	11/21 (52%)
		TM helix 7	784..809	CDD:410628	12/24 (50%)
Hrh2	NP_001399939.1	7tmA_Histamine_H2R	19..298	CDD:320179	109/591 (18%)
		TM helix 1	20..46	CDD:320179	11/25 (44%)
		TM helix 2	53..80	CDD:320179	12/26 (46%)
		TM helix 3	91..121	CDD:320179	18/29 (62%)
		TM helix 4	133..153	CDD:320179	4/19 (21%)
		TM helix 5	178..208	CDD:320179	9/29 (31%)
		TM helix 6	226..256	CDD:320179	16/130 (12%)
		TM helix 7	266..291	CDD:320179	12/24 (50%)