Protein Alignment 5-HT1A and ADRA2C

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_000674.2
• Gene: ADRA2C / 152
• HGNCID: 283
• Length: 462
• Species: Homo sapiens
• Alignment Length: 748
• Identity: 177/748 - (23%)
• Similarity: 267/748 - (35%)
• Gaps: 300/748 - (40%)

  Fly   107 LATAALAAAAASASVAAAAARITAKAAHRALTTKQDATSSPASSPALQLIDMDNNYTNVAV-GLG 170
            :|:.|||||.|   |||||....:.|..|......:|:.:....|..|       |:..|| ||.
Human     1 MASPALAAALA---VAAAAGPNASGAGERGSGGVANASGASWGPPRGQ-------YSAGAVAGLA 55

  Fly   171 AMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGL 235
            |                                                            ::|.
Human    56 A------------------------------------------------------------VVGF 60

  Fly   236 MILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCD 300
            :|:.|::|||.|:.|::..|.|:...|..:.|||.||:.||.||||.....|:...|..|...|.
Human    61 LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCG 125

  Fly   301 IWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFG- 363
            ::.:.|||.||:||:||.||::||||:||. ::|...||..||...|..||..:.::|..|...
Human   126 VYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSL 190

  Fly   364 WKDPD---YLQRIEQQKCMVSQDVSYQVFATCC-TFYVPLLVILALYWKIYQTA--RKRIHRRRP 422
            ::.||   |.|      |.:: |.::.:.::|. :|:.|.|::..:|.:||:.|  |.|....:.
Human   191 YRQPDGAAYPQ------CGLN-DETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKR 248

  Fly   423 RPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNT 487
            .||.       |||.:                .|.::..|:|.|..           .:|:....
Human   249 APVG-------PDGAS----------------PTTENGLGAAAGAG-----------ENGHCAPP 279

  Fly   488 VNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQ 552
            ...||..| ||:..:.:.|.|                    |.::|                ||:
Human   280 PADVEPDE-SSAAAERRRRRG--------------------ALRRG----------------GRR 307

  Fly   553 EDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQL 617
            .                                     ||.
Human   308 R-------------------------------------AGA------------------------ 311

  Fly   618 EQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQS 682
                       .||.|||.                   .||.|..||.:|.:||..|
Human   312 -----------EGGAGGAD-------------------GQGAGPGAAESGALTASRS-------- 338

  Fly   683 HPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRER 747
                         |.|..|......:.......::::.:   ||:.        |::..:| ||:
Human   339 -------------PGPGGRLSRASSRSVEFFLSRRRRAR---SSVC--------RRKVAQA-REK 378

  Fly   748 KAAKTLAIITGAFVVCWLPFFVMALTMPLC-AACQISDSVASLFLWLGYFNSTLNPVIYTIFSPE 811
            :....||::.|.||:||.|||.......:| .|||:...:...|.|:||.||:|||||||:|:.:
Human   379 RFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQD 443

  Fly   812 FRQAFKRILFGGHRPVHYRSGKLXIVHAKRRRR 844
            ||::||.|||                  :||||
Human   444 FRRSFKHILF------------------RRRRR 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	66/191 (35%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	12/25 (48%)
		TM helix 3	299..329	CDD:320454	16/29 (55%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	8/29 (28%)
		7tm_GPCRs	<743..816	CDD:475119	33/73 (45%)
		TM helix 6	750..772	CDD:410628	10/21 (48%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
ADRA2C	NP_000674.2	7tmA_alpha2C_AR	60..448	CDD:320446	144/589 (24%)
		TM helix 2	86..112	CDD:320446	12/25 (48%)
		TM helix 3	124..154	CDD:320446	16/29 (55%)
		TM helix 4	166..189	CDD:320446	7/22 (32%)
		TM helix 5	207..236	CDD:320446	7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..347		40/283 (14%)
		TM helix 6	375..405	CDD:320446	13/30 (43%)
		TM helix 7	416..441	CDD:320446	13/24 (54%)