Protein Alignment 5-HT1A and ADRA1A

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_150646.3
• Gene: ADRA1A / 148
• HGNCID: 277
• Length: 475
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 125/594 - (21%)
• Similarity: 196/594 - (32%)
• Gaps: 287/594 - (48%)

  Fly   231 VLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILG 295
            |:||.:||..::||:.||.::...|:|.:|.:|.:.:||||||.:...|:|..|::|:...|..|
Human    31 VILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95

  Fly   296 PELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVFMMIFCVWTAAVIVSLA 359
            ...|:||.:.|||||||||:.|..|::|||..|: .:.|....|..|..|.:.|||..::::|:.
Human    96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIG 160

  Fly   360 PQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRP 424
            |.|||:.|   ...::..|.::::..|.:|:...:||:||.:||.:|.::|..|     :|..|.
Human   161 PLFGWRQP---APEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVA-----KRESRG 217

  Fly   425 VDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVN 489
            :.:.:..::.|....| .::||
Human   218 LKSGLKTDKSDSEQVT-LRIHR------------------------------------------- 238

  Fly   490 TVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQED 554
                                                                             
Human   239 ----------------------------------------------------------------- 238

  Fly   555 DGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQ 619
                                                                             
Human   239 ----------------------------------------------------------------- 238

  Fly   620 VQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHP 684
                 |:..:||.|.||                                  |||.|..|.
Human   239 -----KNAPAGGSGMAS----------------------------------AKTKTHFSV----- 259

  Fly   685 LCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKA 749
                                                                  ..|:..||:||
Human   260 ------------------------------------------------------RLLKFSREKKA 270

  Fly   750 AKTLAIITGAFVVCWLPFFVMALTMPLCA---ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPE 811
            ||||.|:.|.||:||||||   |.||:.:   ..:.|::|..:..||||.||.:||:||...|.|
Human   271 AKTLGIVVGCFVLCWLPFF---LVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQE 332

  Fly   812 FRQAFKRIL 820
            |::||:.:|
Human   333 FKKAFQNVL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	67/182 (37%)
		TM helix 1	228..254	CDD:320454	9/22 (41%)
		TM helix 2	261..287	CDD:320454	10/25 (40%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	10/28 (36%)
		7tm_GPCRs	<743..816	CDD:475119	36/75 (48%)
		TM helix 6	750..772	CDD:410628	14/21 (67%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
ADRA1A	NP_150646.3	7tmA_alpha1A_AR	27..337	CDD:320448	122/588 (21%)
		TM helix 1	28..54	CDD:320448	9/22 (41%)
		TM helix 2	61..87	CDD:320448	10/25 (40%)
		TM helix 3	99..129	CDD:320448	17/29 (59%)
		TM helix 4	141..164	CDD:320448	7/22 (32%)
		TM helix 5	181..210	CDD:320448	10/28 (36%)
		TM helix 6	265..295	CDD:320448	21/32 (66%)
		TM helix 7	305..330	CDD:320448	11/24 (46%)
		Nuclear localization signal	334..349		3/8 (38%)