Protein Alignment 5-HT1A and ADRA1D

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_000669.1
• Gene: ADRA1D / 146
• HGNCID: 280
• Length: 572
• Species: Homo sapiens
• Alignment Length: 704
• Identity: 156/704 - (22%)
• Similarity: 229/704 - (32%)
• Gaps: 316/704 - (44%)

  Fly   145 SSPASSPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGT---G 206
            ::|:..||:..:..........||.|:.        |.|.||......|...|.   :|||   |
Human    35 AAPSEGPAVGGVPGGAGGGGGVVGAGSG--------EDNRSSAGEPGSAGAGGD---VNGTAAVG 88

  Fly   207 GLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVA 271
            ||.|:...|.            ..|.|...||:.:.||:.||.::...|:||.|.||.:.:||||
Human    89 GLVVSAQGVG------------VGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVA 141

  Fly   272 DLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIH 335
            ||.::..|:|..|..|:...|..|...||:|.:.||||||||||.|..|:||||..|. ::.|..
Human   142 DLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPA 206

  Fly   336 SRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLL 400
            ..|..:...::..:|..|::||:.|..|||:|   ...:::.|.::::..|.||::.|:||:|:.
Human   207 IMTERKAAAILALLWVVALVVSVGPLLGWKEP---VPPDERFCGITEEAGYAVFSSVCSFYLPMA 268

  Fly   401 VILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAV 465
            ||:.:|.::|..||.     ..|.::|.|...:   |.|::..| |:..|           |:|.
Human   269 VIVVMYCRVYVVARS-----TTRSLEAGVKRER---GKASEVVL-RIHCR-----------GAAT 313

  Fly   466 GVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAK 530
            |..| |.|.|                                     |..|:
Human   314 GADG-AHGMR-------------------------------------SAKGH------------- 327

  Fly   531 QQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNE 595
                 |.:||.:|
Human   328 -----TFRSSLSV---------------------------------------------------- 335

  Fly   596 SEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVG 660
                                                                             
Human   336 ----------------------------------------------------------------- 335

  Fly   661 IAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLS 725
                                                                             
Human   336 ----------------------------------------------------------------- 335

  Fly   726 SIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLF 790
                         ..|:..||:||||||||:.|.||:||.|||.:.....|....:.|:.|..:.
Human   336 -------------RLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVI 387

  Fly   791 LWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKLXIVHAKRRRR 844
            .|||||||.:||:||...|.||::||.|:|               ....:||||
Human   388 FWLGYFNSCVNPLIYPCSSREFKRAFLRLL---------------RCQCRRRRR 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	69/186 (37%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	19/29 (66%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:475119	35/72 (49%)
		TM helix 6	750..772	CDD:410628	14/21 (67%)
		TM helix 7	784..809	CDD:410628	12/24 (50%)
ADRA1D	NP_000669.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..77		11/49 (22%)
		7tmA_alpha1D_AR	97..413	CDD:320450	129/601 (21%)
		TM helix 1	98..124	CDD:320450	8/37 (22%)
		TM helix 2	131..157	CDD:320450	11/25 (44%)
		TM helix 3	169..199	CDD:320450	19/29 (66%)
		TM helix 4	211..234	CDD:320450	5/22 (23%)
		TM helix 5	251..280	CDD:320450	11/28 (39%)
		TM helix 6	341..371	CDD:320450	18/29 (62%)
		TM helix 7	381..406	CDD:320450	12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..488