DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and ADORA2B

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_000667.1 Gene:ADORA2B / 136 HGNCID:264 Length:332 Species:Homo sapiens


Alignment Length:210 Identity:66/210 - (31%)
Similarity:96/210 - (45%) Gaps:26/210 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 VLLGLMI-LVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWIL 294
            |.|.|:| .:::.|||.|.||:.....||...||.:.|||.||:.|....:|....  ||.|:..
Human    11 VALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAIT--ISLGFCT 73

  Fly   295 GPELCDIWTSCDVLCCT-ASILHLVAIAVDRYWAV-TNIDYIHSRTSNRVFMMIFCVWTAAVIVS 357
            ....| ::.:|.||..| :||..|:|:|||||.|: ..:.|....|..|...:|..:|..|..:.
Human    74 DFYGC-LFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIG 137

  Fly   358 LAPQFGWKDPDYLQR---------IEQQKCMVS------QDVSYQV---FATCCTFYVPLLVILA 404
            |.|..||...|....         ..:..|:|.      ..:||.|   |..|  ...|||::|.
Human   138 LTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGC--VLPPLLIMLV 200

  Fly   405 LYWKIYQTARKRIHR 419
            :|.||:..|.:::.|
Human   201 IYIKIFLVACRQLQR 215

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 64/202 (32%)
TM helix 1 228..254 CDD:320454 10/23 (43%)
TM helix 2 261..287 CDD:320454 9/25 (36%)
TM helix 3 299..329 CDD:320454 15/31 (48%)
TM helix 4 340..362 CDD:320454 6/21 (29%)
TM helix 5 383..412 CDD:320454 12/31 (39%)
7tm_GPCRs <743..816 CDD:475119
TM helix 6 750..772 CDD:410628
TM helix 7 784..809 CDD:410628
ADORA2BNP_000667.1 7tmA_Adenosine_R_A2B 8..301 CDD:320197 66/210 (31%)
TM helix 1 9..35 CDD:320197 10/23 (43%)
TM helix 2 42..69 CDD:320197 10/28 (36%)
TM helix 3 78..108 CDD:320197 15/30 (50%)
TM helix 4 122..140 CDD:320197 4/17 (24%)
TM helix 5 179..209 CDD:320197 12/31 (39%)
TM helix 6 227..257 CDD:320197
TM helix 7 269..294 CDD:320197
Blue background indicates that the domain is not in the aligned region.

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