DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and ADORA2A

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_000666.2 Gene:ADORA2A / 135 HGNCID:263 Length:412 Species:Homo sapiens


Alignment Length:244 Identity:80/244 - (32%)
Similarity:121/244 - (49%) Gaps:29/244 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWIL 294
            :|.|.:.:| .|:|||.|..|:.|..|||||.||.|.|||.||:.|..|.:|....  ||.|:..
Human    11 TVELAIAVL-AILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCA 72

  Fly   295 GPELCDIWTSCDVLCCT-ASILHLVAIAVDRYWAV-TNIDYIHSRTSNRVFMMIFCVWTAAVIVS 357
            ....| ::.:|.||..| :||..|:|||:|||.|: ..:.|....|..|...:|...|..:..:.
Human    73 ACHGC-LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIG 136

  Fly   358 LAPQFGWKD-------PDYLQRI-EQQKCMVSQDV---SYQV---FATCCTFYVPLLVILALYWK 408
            |.|..||.:       .::.|.. |.|...:.:||   :|.|   |..|  ..||||::|.:|.:
Human   137 LTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFAC--VLVPLLLMLGVYLR 199

  Fly   409 IYQTARKRIHR--RRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFS 455
            |:..||:::.:  .:|.|.:.|.:..|.:..||..     |.:.:|.|:
Human   200 IFLAARRQLKQMESQPLPGERARSTLQKEVHAAKS-----LAIIVGLFA 243

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 69/198 (35%)
TM helix 1 228..254 CDD:320454 9/23 (39%)
TM helix 2 261..287 CDD:320454 11/25 (44%)
TM helix 3 299..329 CDD:320454 15/31 (48%)
TM helix 4 340..362 CDD:320454 5/21 (24%)
TM helix 5 383..412 CDD:320454 13/34 (38%)
7tm_GPCRs <743..816 CDD:475119
TM helix 6 750..772 CDD:410628
TM helix 7 784..809 CDD:410628
ADORA2ANP_000666.2 7tmA_Adenosine_R_A2A 7..299 CDD:320196 80/244 (33%)
TM helix 1 8..34 CDD:320196 9/23 (39%)
TM helix 2 41..68 CDD:320196 12/28 (43%)
TM helix 3 77..107 CDD:320196 15/30 (50%)
TM helix 4 121..139 CDD:320196 3/17 (18%)
TM helix 5 174..204 CDD:320196 11/31 (35%)
TM helix 6 226..256 CDD:320196 6/23 (26%)
TM helix 7 267..292 CDD:320196
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..412
Blue background indicates that the domain is not in the aligned region.

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