DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Drd4

DIOPT Version :9

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_031904.1 Gene:Drd4 / 13491 MGIID:94926 Length:387 Species:Mus musculus


Alignment Length:645 Identity:158/645 - (24%)
Similarity:219/645 - (33%) Gaps:269/645 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 GNDSSL-FGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTII--G 243
            ||.|:. .|.:||.| |...|..|.|                 |..|..:.|:|.::|:.::  |
Mouse     2 GNSSATEDGGLLAGR-GPESLGTGAG-----------------LGGAGAAALVGGVLLIGLVLAG 48

  Fly   244 NVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG-WILGPELCDIWTSCDV 307
            |..|..::..||.||...||.:.|||.|||.:|.||:||....|:..| |:|.|.|||...:.||
Mouse    49 NSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDV 113

  Fly   308 LCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKD-PDYLQ 371
            :.|||||.:|.||:|||:.||| :...:::......::|...|..:..|:.....|..| |.   
Mouse   114 MLCTASIFNLCAISVDRFVAVT-VPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPG--- 174

  Fly   372 RIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDG 436
            |.....|:.::|  |.|:::.|:|::|..::|.|||..::..|:                    .
Mouse   175 RDPAVCCLENRD--YVVYSSVCSFFLPCPLMLLLYWATFRGLRR--------------------W 217

  Fly   437 GAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNV 501
            .||..||||.        ...:..:|....||.|..|                     .|..   
Mouse   218 EAARHTKLHS--------RAPRRPSGPGPPVSDPTQG---------------------PFFP--- 250

  Fly   502 DSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGR-QEDDGQRPEHGEQE 565
                    :.|..                                .||.| ...|..|||     
Mouse   251 --------DCPPP--------------------------------LPSLRTSPSDSSRPE----- 270

  Fly   566 DREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSG 630
                                                                             
Mouse   271 ----------------------------------------------------------------- 270

  Fly   631 GGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPST 695
                            |.|| |.|.|.|..:|.||.                          |..
Mouse   271 ----------------SELS-QRPCSPGCLLADAAL--------------------------PQP 292

  Fly   696 PEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAF 760
            |||.||                                  :|:......|||||.:.|.::.|||
Mouse   293 PEPSSR----------------------------------RRRGAKITGRERKAMRVLPVVVGAF 323

  Fly   761 VVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            :|||.||||:.:|..||.||.:|..:.|...||||.||.|||:|||||:.|||..|::.|
Mouse   324 LVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTL 383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 66/189 (35%)
TM helix 1 228..254 CDD:320454 6/27 (22%)
TM helix 2 261..287 CDD:320454 13/25 (52%)
TM helix 3 299..329 CDD:320454 16/29 (55%)
TM helix 4 340..362 CDD:320454 3/21 (14%)
TM helix 5 383..412 CDD:320454 10/28 (36%)
7tm_GPCRs <743..816 CDD:355774 40/72 (56%)
TM helix 6 747..772 CDD:341315 14/24 (58%)
TM helix 7 784..809 CDD:341315 14/24 (58%)
Drd4NP_031904.1 7tm_1 48..368 CDD:278431 132/564 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 224..247 8/51 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..306 9/78 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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