Protein Alignment 5-HT1A and Drd2

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_034207.2
• Gene: Drd2 / 13489
• MGIID: 94924
• Length: 444
• Species: Mus musculus
• Alignment Length: 602
• Identity: 160/602 - (26%)
• Similarity: 236/602 - (39%)
• Gaps: 208/602 - (34%)

  Fly   230 SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWIL 294
            ::||.|:|.:.:.|||.|..|:..|:.||...|||:.|||||||.||.||||.....|:...|..
Mouse    38 AMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF 102

  Fly   295 GPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSN--RVFMMIFCVWTAAVIVS 357
            ....|||:.:.||:.||||||:|.||::|||.||......::|.|:  ||.:||..||..:..:|
Mouse   103 SRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTIS 167

  Fly   358 LAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRP 422
            ....||      |...:|.:|::: :.::.|:::..:||||.:|.|.:|.|||...|||  |:|
Mouse   168 CPLLFG------LNNTDQNECIIA-NPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKR--RKR- 222

  Fly   423 RPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNT 487
                             .:||      |..|...|..||.                 :.||.|:.
Mouse   223 -----------------VNTK------RSSRAFRANLKTP-----------------LKGNCTHP 247

  Fly   488 VNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQ 552
                ||.:..:  |..||                                      ||..|..|:
Mouse   248 ----EDMKLCT--VIMKS--------------------------------------NGSFPVNRR 268

  Fly   553 EDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQL 617
            ..|..|
Mouse   269 RMDAAR----------------------------------------------------------- 274

  Fly   618 EQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQS 682
             :.|:|:..:                  :|:.||...|..         .|:......||..:.|
Mouse   275 -RAQELEMEM------------------LSSTSPPERTRY---------SPIPPSHHQLTLPDPS 311

  Fly   683 HPLCGTANESPSTPE---------PRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRK 738
            |....:..:||:.||         ||..:....|..|:.:..             ..::.:::||
Mouse   312 HHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTR-------------TSLKTMSRRK 363

  Fly   739 ETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPV 803
              |..::|:||.:.|||:.|.|::||||||:..:....| .|.|...:.|.|.||||.||.:||:
Mouse   364 --LSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHC-DCNIPPVLYSAFTWLGYVNSAVNPI 425

  Fly   804 IYTIFSPEFRQAFKRIL 820
            |||.|:.|||:||.:||
Mouse   426 IYTTFNIEFRKAFMKIL 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	74/184 (40%)
		TM helix 1	228..254	CDD:320454	9/23 (39%)
		TM helix 2	261..287	CDD:320454	16/25 (64%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	7/23 (30%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:475119	34/72 (47%)
		TM helix 6	750..772	CDD:410628	11/21 (52%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
Drd2	NP_034207.2	7tmA_D2_dopamine_R	35..438	CDD:320435	156/596 (26%)
		TM helix 1	36..62	CDD:320435	9/23 (39%)
		TM helix 2	69..92	CDD:320435	16/22 (73%)
		TM helix 3	107..137	CDD:320435	18/29 (62%)
		TM helix 4	152..170	CDD:320435	6/17 (35%)
		TM helix 5	186..211	CDD:320435	8/24 (33%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..374		54/351 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..329		13/73 (18%)
		TM helix 6	367..397	CDD:320435	14/29 (48%)
		TM helix 7	406..431	CDD:320435	13/24 (54%)