DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Drd1

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_034206.1 Gene:Drd1 / 13488 MGIID:99578 Length:446 Species:Mus musculus


Alignment Length:630 Identity:134/630 - (21%)
Similarity:201/630 - (31%) Gaps:316/630 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 TSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQN-VANYLVASLAVADLFV 275
            |....|.||:..:   :|:..|.|:||.|::||..|.||:|..|:|:: |.|:.|.||||:||.|
Mouse    11 TGLPVERDFSFRI---LTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLV 72

  Fly   276 ACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTS 339
            |.||||..||.||:..|..| ..|:||.:.|::|.|||||:|..|:||||||::: ..|....|.
Mouse    73 AVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTP 136

  Fly   340 NRVFMMIFCVWTAAVIVSLAP-QFGWK--------DPDY--LQRIEQQKCMVSQDVSYQVFATCC 393
            ...|::|...||.:|::|..| |..|.        |.::  |:..|...|......:|.:.::..
Mouse   137 KAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLI 201

  Fly   394 TFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAK 458
            :||:|:.:::..|..||:.|:|:|.|                                       
Mouse   202 SFYIPVAIMIVTYTSIYRIAQKQIRR--------------------------------------- 227

  Fly   459 SKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEA---PSTSGNQIA 520
                                                      :.:..||.|.|   .:|:||   
Mouse   228 ------------------------------------------ISALERAAVHAKNCQTTTGN--- 247

  Fly   521 TVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTAT 585
                                                                             
Mouse   248 ----------------------------------------------------------------- 247

  Fly   586 SAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALS 650
                            .|.||                                            
Mouse   248 ----------------GNPVE-------------------------------------------- 252

  Fly   651 PQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAH 715
                                        |:||.                                
Mouse   253 ----------------------------CSQSE-------------------------------- 257

  Fly   716 QQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAAC 780
                     ||.            .:..|||.|..|||::|.|.||.||||||:....:|.|.:.
Mouse   258 ---------SSF------------KMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSE 301

  Fly   781 QIS----DSVA-SLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            :..    ||:. .:|:|.|:.||:|||:||. |:.:|::||..:|
Mouse   302 ETQPFCIDSITFDVFVWFGWANSSLNPIIYA-FNADFQKAFSTLL 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 75/198 (38%)
TM helix 1 228..254 CDD:320454 12/25 (48%)
TM helix 2 261..287 CDD:320454 16/25 (64%)
TM helix 3 299..329 CDD:320454 18/29 (62%)
TM helix 4 340..362 CDD:320454 7/22 (32%)
TM helix 5 383..412 CDD:320454 7/28 (25%)
7tm_GPCRs <743..816 CDD:475119 33/77 (43%)
TM helix 6 750..772 CDD:410628 13/21 (62%)
TM helix 7 784..809 CDD:410628 12/25 (48%)
Drd1NP_034206.1 7tm_GPCRs 22..341 CDD:475119 127/613 (21%)
TM helix 1 25..49 CDD:410628 11/23 (48%)
TM helix 2 59..81 CDD:410628 14/21 (67%)
TM helix 3 96..118 CDD:410628 11/21 (52%)
TM helix 4 141..157 CDD:410628 5/15 (33%)
TM helix 5 192..215 CDD:410628 4/22 (18%)
TM helix 6 271..293 CDD:410628 13/21 (62%)
TM helix 7 310..335 CDD:410628 12/25 (48%)

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