DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and TAAR1

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_612200.1 Gene:TAAR1 / 134864 HGNCID:17734 Length:339 Species:Homo sapiens


Alignment Length:621 Identity:103/621 - (16%)
Similarity:174/621 - (28%) Gaps:313/621 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 NVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADL 273
            |:......:::::..:|.::.|::: |:||.|::||:.||.:|...:.|....|:|:.|:|..|.
Human     7 NIINISCVKNNWSNDVRASLYSLMV-LIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDF 70

  Fly   274 FVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSR 337
            .:.|||||...|......|..|...|.|.||.|::..:|||.||..|::|||:||.: :.|....
Human    71 LLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKM 135

  Fly   338 TSNRVFMMIFCVWTAAVI-----VSLAPQFGWKDPDYLQRIE-QQKCMVSQDVSYQVFATCCTFY 396
            ....:.:|||..|:...:     :.|...|...:..|.:.:. :..|.|.......|.....:||
Human   136 NILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFY 200

  Fly   397 VPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKT 461
            :|..::|.:|::||                                                   
Human   201 IPGSIMLCVYYRIY--------------------------------------------------- 214

  Fly   462 GSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLV 526
                                                                             
Human   215 ----------------------------------------------------------------- 214

  Fly   527 ALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAA 591
            .:||:|.:..:.::                                                   
Human   215 LIAKEQARLISDAN--------------------------------------------------- 228

  Fly   592 GTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTS 656
                                         |:||                                
Human   229 -----------------------------QKLQ-------------------------------- 232

  Fly   657 QGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQ 721
              :|:                                                            
Human   233 --IGL------------------------------------------------------------ 235

  Fly   722 QQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSV 786
                          :.|..:...:||||.|||.|:.|.|::||.|||:..:..|..... |..::
Human   236 --------------EMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYI-IPPTL 285

  Fly   787 ASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFG 822
            ..:.:|.||.|||.||::|..|.|.||:|.|.:|||
Human   286 NDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFG 321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 58/192 (30%)
TM helix 1 228..254 CDD:320454 10/25 (40%)
TM helix 2 261..287 CDD:320454 11/25 (44%)
TM helix 3 299..329 CDD:320454 15/29 (52%)
TM helix 4 340..362 CDD:320454 5/26 (19%)
TM helix 5 383..412 CDD:320454 8/28 (29%)
7tm_GPCRs <743..816 CDD:475119 30/72 (42%)
TM helix 6 750..772 CDD:410628 11/21 (52%)
TM helix 7 784..809 CDD:410628 9/24 (38%)
TAAR1NP_612200.1 7tmA_TAAR1 26..315 CDD:320438 96/594 (16%)
TM helix 1 26..51 CDD:320438 10/25 (40%)
TM helix 2 58..84 CDD:320438 11/25 (44%)
TM helix 3 96..126 CDD:320438 15/29 (52%)
TM helix 4 138..161 CDD:320438 4/22 (18%)
Extracellular Loop 2 (ECL2). /evidence=ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465 175..186 2/10 (20%)
TM helix 5 187..216 CDD:320438 8/144 (6%)
TM helix 6 244..274 CDD:320438 15/29 (52%)
TM helix 7 283..308 CDD:320438 9/24 (38%)

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