Protein Alignment 5-HT1A and TAAR9

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 104/611 - (17%)
• Similarity: 153/611 - (25%)
• Gaps: 330/611 - (54%)

  Fly   227 AVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG 291
            ::...:||...::...||:.|:.||:..:.|....|:|:||||.||..|...|||...|..:...
Human    33 SILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESC 97

  Fly   292 WILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCV---WTAA 353
            |..|...|...|..|...|.||:.||..|:||||.|||  |.:...|...|.:...|:   |..:
Human    98 WYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVT--DPLTYPTKFTVSVSGICIVLSWFFS 160

  Fly   354 VIVSLAPQFGWKDPDYLQRIEQQKCMVS--QDVSYQVFATCC--TFYVPLLVILALYWKIYQTAR 414
            |..|.:..:...:.:.::.:......|.  |....|.:...|  .|::|.:.::.:|.||:..|:
Human   161 VTYSFSIFYTGANEEGIEELVVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAK 225

  Fly   415 KRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGL 479
                                          |:.|
Human   226 ------------------------------HQAR------------------------------- 229

  Fly   480 VDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVN 544
                      .:|.|                                       .|.|:||:
Human   230 ----------KIEST---------------------------------------ASQAQSSS--- 242

  Fly   545 GMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLE 609
                                      |...|:|
Human   243 --------------------------ESYKERV-------------------------------- 249

  Fly   610 DPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTS 674
                                                                             
Human   250 ----------------------------------------------------------------- 249

  Fly   675 TLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKE 739
                                                                             
Human   250 ----------------------------------------------------------------- 249

  Fly   740 TLEAKRERKAAKTLAIITGAFVVCWLPFFVMA--------LTMPLCAACQISDSVASLFLWLGYF 796
               |||||||||||.|...||:|.|||:.|.|        :|.|.         |..:.:|..|:
Human   250 ---AKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPY---------VYEILVWCVYY 302

  Fly   797 NSTLNPVIYTIFSPEFRQAFKRILFG 822
            ||.:||:||..|...|.:|.|.|:.|
Human   303 NSAMNPLIYAFFYQWFGKAIKLIVSG 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	55/192 (29%)
		TM helix 1	228..254	CDD:320454	7/25 (28%)
		TM helix 2	261..287	CDD:320454	13/25 (52%)
		TM helix 3	299..329	CDD:320454	14/29 (48%)
		TM helix 4	340..362	CDD:320454	5/24 (21%)
		TM helix 5	383..412	CDD:320454	7/30 (23%)
		7tm_GPCRs	<743..816	CDD:475119	33/80 (41%)
		TM helix 6	750..772	CDD:410628	13/29 (45%)
		TM helix 7	784..809	CDD:410628	9/24 (38%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	100/603 (17%)
		TM helix 1	34..60	CDD:320439	7/25 (28%)
		TM helix 2	67..93	CDD:320439	13/25 (52%)
		TM helix 3	105..135	CDD:320439	14/29 (48%)
		TM helix 4	147..170	CDD:320439	4/22 (18%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		0/12 (0%)
		TM helix 5	194..223	CDD:320439	7/28 (25%)
		TM helix 6	251..281	CDD:320439	19/29 (66%)
		TM helix 7	290..315	CDD:320439	10/33 (30%)