Protein Alignment 5-HT1A and LOC1273080

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_061498027.1
• Gene: LOC1273080 / 1273080
• VectorBaseID: AGAMI1_014239
• Length: 1236
• Species: Anopheles gambiae
• Alignment Length: 1252
• Identity: 246/1252 - (19%)
• Similarity: 373/1252 - (29%)
• Gaps: 566/1252 - (45%)

  Fly    92 PPT---DVNTTTTTAGSPLATAALAAAAASASVAAAAARITAKAAHRALTTKQDATSSPASSPAL 153
            |||   :||.....|..|:......|..|||..:|.:|.:|:.|            .:|.|...
Mosquito     8 PPTAQPEVNALLGAATQPITLPGALATVASALASAGSATLTSLA------------MAPTSGGP- 59

  Fly   154 QLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLIN-GTGGLNV---TTSK 214
               ::|    ..|.|     .|.|           |:..:..:|....:. ||..:|:   |.|.
Mosquito    60 ---EVD----GAAGG-----WNGT-----------GDATSGAAGDHQPVGPGTNAVNLTVPTAST 101

  Fly   215 VAE--DDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVAC 277
            :.|  |...:|..:.:.|::.|.:|:..::||..||.::...|.|:.:.||.|.|||:||:.||.
Mosquito   102 IVEPADRLVELTVLCLKSLIFGSIIIGAVLGNALVIISVHKNRKLRVITNYFVVSLAMADMLVAL 166

  Fly   278 LVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNR 341
            ..|...|..|:|..|:.|..:||:|.|.||...|||||||..|:||||:|:.. ::|....|...
Mosquito   167 CAMTFNASVELSGRWLFGSFMCDVWNSLDVYFSTASILHLCCISVDRYFAIVRPLEYPLYMTQRT 231

  Fly   342 VFMMIFCVWTAAVIVSLAPQF-GW-KDPDYLQ--RIEQQKCMVSQDVSYQVFATCCTFYVPLLVI 402
            ||.|:..||....::|..|.| || ...::|.  :|....|:...:.||.:.::..:|::|.:|:
Mosquito   232 VFFMLANVWVLPALISFTPIFLGWYTTAEHLAALKINPDLCIFVVNKSYAIISSSISFWIPGIVM 296

  Fly   403 LALYWKIYQTA---RK---------------------------------------RIHRRRPRPV 425
            :.:|::||:.|   ||                                       |.|..|....
Mosquito   297 VTMYYRIYKEAVRQRKALSRTSSNILLNSVQINNASNTLHANHHHHNHHHQHLHHRNHHLRASDC 361

  Fly   426 DAAVNNNQ-------------------PDGGAATD----------TKLHRLRLRL--------GR 453
            |..::...                   |...|.||          .:|.|..:.|        |:
Mosquito   362 DLGIDIKDIQHDTHSELSDLDLQVPIVPTVVANTDDDFLVPSSPPRRLSRSSIDLRDLEYKGEGK 426

  Fly   454 FSTAKS----------------------------------------------------------- 459
            ...:.|
Mosquito   427 IKASDSVSSIFPLHYENNLRYSGSEPIHIKEAQQQQQQQQQPNDQQQRRASRKDSFRQINFFQPF 491

  Fly   460 -------KT---GSAVGVSGPASGG----RALGLVDGNST----NTVNTVEDTEFSSSNVDSKSR 506
                   ||   |.|.|..|...||    ..:|.|.|:::    |.:|.....|.::.|.|::|.
Mosquito   492 FSRNSLLKTYIKGGAGGAGGGGGGGGGGSGTVGAVTGSASAIAGNQLNNNRSVERNNKNNDNRSN 556

  Fly   507 AGV------------------EAPSTSGNQIAT-------------------------------- 521
            ..:                  |..:...:|||.
Mosquito   557 NNILDLINVASSLNKGGDSEKEMNTHKRHQIAASESDFLTMIEKQRQKLGKNTNSLKNCNKDEKE 621

  Fly   522 -------VSHLVALAKQQ---------------GKSTAKS---SAAVNGMAPSGRQEDDGQRP-- 559
                   ....|.|.|||               |...|:.   ...:||....|..|..|..|
Mosquito   622 LMYALSDSDFSVGLQKQQQQDEGVARRCFKNLVGSEVARDGIFKIVLNGEGNGGASETGGASPAA 686

  Fly   560 ------------------------------EHGEQEDREELED-------QDEQVGPQPTTATSA 587
                                          :||....|..|..       .||  |.....::..
Mosquito   687 VGLAGGVDGGTESVIGSGTMGTPDILIGCFDHGFTGSRPALNSPTVKELVADE--GALIKASSLK 749

  Fly   588 MTAAGTNESEDQCKANGVEVLE-----------------------DPQLQQQL------------ 617
            :|..|...||.  .|.|.:|::                       |.||...|
Mosquito   750 VTDRGDGTSEP--TAEGAKVIDLISTINGPAGEDGVRSVKPPAGPDNQLSTALNVSLNARCSPVN 812

  Fly   618 -------------------EQVQQLQKS-------------------------VKSGGGGGASTS 638
                               |::.::..|                         :.:...|...:.
Mosquito   813 IQLSEASTISLDLVATSPKEKLPKVPTSAPATVTTIDIASEMMMMLADNPDIVIDNSHTGATVSP 877

  Fly   639 NATTITSISALSPQTPTSQ-----------------------------------------GVGIA 662
            .:.|:|...|.|..||:.|                                         |.|..
Mosquito   878 TSRTVTPSRAPSIMTPSPQHHPRLGRKRQSSTVTYNINVINFQAGDNPDDDASFQLNNRNGNGGG 942

  Fly   663 AAAAGPMTAKTSTLTSCNQSHPLCGT------------ANESPSTPEPRSRQPTTPQQQ---PHQ 712
            .|.||   .::::.||.:|.|...|.            ||::.:..|......|..||.   .||
Mosquito   943 TATAG---GRSNSSTSSSQKHQRRGAICIVINNDNVVHANDTDTDLEEDGCCATAAQQHRNYQHQ 1004

  Fly   713 QAHQQQQQQQQ---------------------------------------LSSIANPMQKVNKRK 738
            ..||.||||||                                       :..:.|.:::...|:
Mosquito  1005 HDHQHQQQQQQQHQPQQRYANQPGCCYGGGGRHQDDGSGAASCRHHKFRKIKCLWNHLKRYGLRR 1069

  Fly   739 E--------------------TLEA---------------------------------------- 743
            .                    |:..
Mosquito  1070 SGPSVQVSSCGGACDFGPPSPTVSTGAGGAGGNRLAVPSPVPPGCRHSRCSSVGCGEGGTSTRPS 1134

  Fly   744 ---KRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA--ACQISDSVASLFLWLGYFNSTLNPV 803
               :.|.|||:||.||.|.|::||||||:..:...||.  ||...|.|.::..|:|||||||||:
Mosquito  1135 KGWRAEHKAARTLGIIMGVFLLCWLPFFLWYVITTLCGEEACPCPDVVITVLFWIGYFNSTLNPL 1199

  Fly   804 IYTIFSPEFRQAFKRIL 820
            ||..|:.:||:||:..|
Mosquito  1200 IYAYFNRDFREAFRNTL 1216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	67/190 (35%)
		TM helix 1	228..254	CDD:320454	7/25 (28%)
		TM helix 2	261..287	CDD:320454	12/25 (48%)
		TM helix 3	299..329	CDD:320454	19/29 (66%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	8/28 (29%)
		7tm_GPCRs	<743..816	CDD:475119	37/117 (32%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	14/24 (58%)
LOC1273080	XP_061498027.1	None