Protein Alignment 5-HT1A and AdoR

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_310647.2
• Gene: AdoR / 1271793
• VectorBaseID: AGAMI1_006181
• Length: 392
• Species: Anopheles gambiae
• Alignment Length: 642
• Identity: 124/642 - (19%)
• Similarity: 186/642 - (28%)
• Gaps: 291/642 - (45%)

  Fly   189 GEMLANRSGQLDLINGTGGL-NVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAII 252
            |.:..|.:.:....|||.|. |.|..:..|......|..|:....:.||   .|.||..||.|..
Mosquito     5 GLLAGNATDECLRANGTPGWGNGTGDEPPEAPVRLNLPYALLEATVALM---AIFGNTLVIVAFR 66

  Fly   253 LERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHL 317
            .||.|:...||.:.|||.|||.|..|.:|...:..|  |.......|....|..|:.||.||..|
Mosquito    67 TERRLRRRTNYYIVSLASADLLVGTLGIPFAVLASI--GLPRNLHACLFTISLLVVLCTISIFCL 129

  Fly   318 VAIAVDRYWAVTN-IDYIHS-RTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMV 380
            ||:::|||||:.: :.|..: ||...::::..| |.|..||...|.|||.     ::..:..|:.
Mosquito   130 VAVSIDRYWAILHPLAYSRNMRTKTTLYIISMC-WLAGFIVGFLPLFGWH-----EQPAEDACLF 188

  Fly   381 SQDVSYQ--VFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTK 443
            .:.::|.  ||....|..:|.:::||.|..||:.    |.|:|
Mosquito   189 VKVMNYDYLVFLYLVTIIIPAVLLLAFYIHIYRV----IVRQR---------------------- 227

  Fly   444 LHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAG 508
                                                                             
Mosquito   228 ----------------------------------------------------------------- 227

  Fly   509 VEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQ 573
                    .||.:|
Mosquito   228 --------KQILSV--------------------------------------------------- 233

  Fly   574 DEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTS 638
                                |..:.:|.|                       |::.|.|
Mosquito   234 --------------------NSIDSRCMA-----------------------SIEDGTG------ 249

  Fly   639 NATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQP 703
                                                   ||:||
Mosquito   250 ---------------------------------------SCSQS--------------------- 254

  Fly   704 TTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFF 768
                     ..|..:::.|:....:..|.:|.:..:    .||.||.:.|:||...|::||:|..
Mosquito   255 ---------GRHATKRRTQRKDQYSGTMLRVLRAAQ----NREVKATQNLSIIVLFFMLCWMPLH 306

  Fly   769 VMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRI---LFG 822
            .:...:..|..|.|...|..|.:.|.:.||.|||::|.....:||.|.||:   |||
Mosquito   307 TINCIVAFCPQCHIHAPVMLLVITLSHLNSALNPLLYAYHLKDFRAALKRLLLSLFG 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	63/189 (33%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	15/29 (52%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	10/30 (33%)
		7tm_GPCRs	<743..816	CDD:475119	25/72 (35%)
		TM helix 6	750..772	CDD:410628	7/21 (33%)
		TM helix 7	784..809	CDD:410628	9/24 (38%)
AdoR	XP_310647.2	None