Protein Alignment 5-HT1A and LOC1269968

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_061499186.1
• Gene: LOC1269968 / 1269968
• VectorBaseID: AGAMI1_010361
• Length: 587
• Species: Anopheles gambiae
• Alignment Length: 714
• Identity: 355/714 - (49%)
• Similarity: 421/714 - (58%)
• Gaps: 163/714 - (22%)

  Fly   143 ATSSPASSPALQLIDMD----NNYTNVAVG-LGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDL- 201
            ||:...::.....|.:|    ::|.:..|| :|    |:|..   |:|:   ...||.:   ||
Mosquito    15 ATALSKANDVYDYIFIDSGSPDSYLSADVGSIG----NETFF---NESA---NAFANTT---DLG 66

  Fly   202 -----INGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVA 261
                 ||||          |::....::.||:||::||||||||:||||||||||||||||||||
Mosquito    67 PVPASINGT----------ADEPLADVIVMAITSLVLGLMILVTVIGNVFVIAAIILERNLQNVA 121

  Fly   262 NYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYW 326
            ||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||.||||
Mosquito   122 NYLVASLAVADLFVACLVMPLGAVYEISRGWILGPELCDIWTSCDVLCCTASILHLVAIATDRYW 186

  Fly   327 AVTNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFAT 391
            |||||||||||||.|||.|||.||.|:||||||||||||||:||||||||||||||:::||||||
Mosquito   187 AVTNIDYIHSRTSRRVFTMIFLVWFASVIVSLAPQFGWKDPEYLQRIEQQKCMVSQNIAYQVFAT 251

  Fly   392 CCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFST 456
            ||||||||.|||.||||||||||:|||||.|:......::||.:    |.....::|..|.:..|
Mosquito   252 CCTFYVPLFVILVLYWKIYQTARRRIHRRGPKIPATPNSSNQEE----TPKPKSKIRFHLKKKFT 312

  Fly   457 AKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSG----- 516
              :.|.|||.         :||||:||||||||||||||.|::|  :..|.|:|. :.||
Mosquito   313 --NPTKSAVS---------SLGLVEGNSTNTVNTVEDTEDSTAN--AADRKGLET-TFSGDEGNG 363

  Fly   517 -----NQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQ 576
                 |||.|||:.|         |.:..|...|.:.|....:.|:
Mosquito   364 TPLGNNQIPTVSYEV---------THQQLAQAAGCSESNNNNNPGR------------------- 400

  Fly   577 VGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNAT 641
                  |.::..|:                                      ..|.||....:..
Mosquito   401 ------TGSAGKTS--------------------------------------PSGNGGTLPGSTY 421

  Fly   642 TITSISALSPQTPTS-QGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTT 705
            .:.::.|.||..|.. |....|.||..|....|:.||..:....|.|....|
Mosquito   422 PVQAVHASSPLLPPQHQHHNAATAAKQPAGTPTAHLTPGSAGSGLQGAGGGS------------- 473

  Fly   706 PQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVM 770
                           ...::|..||..:|:|||||||||||||||||||||||||||||||||:.
Mosquito   474 ---------------TLNIASTPNPQAQVSKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFLT 523

  Fly   771 ALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKL 834
            ||.:|||.:|.|:|:|||||||||||||||||||||||||||||||||||||.||..:||.|||
Mosquito   524 ALLLPLCESCSINDTVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGTHRSANYRRGKL 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	168/185 (91%)
		TM helix 1	228..254	CDD:320454	21/25 (84%)
		TM helix 2	261..287	CDD:320454	25/25 (100%)
		TM helix 3	299..329	CDD:320454	28/29 (97%)
		TM helix 4	340..362	CDD:320454	16/21 (76%)
		TM helix 5	383..412	CDD:320454	23/28 (82%)
		7tm_GPCRs	<743..816	CDD:475119	63/72 (88%)
		TM helix 6	750..772	CDD:410628	19/21 (90%)
		TM helix 7	784..809	CDD:410628	23/24 (96%)
LOC1269968	XP_061499186.1	None