Protein Alignment 5-HT1A and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_061500179.1
• Gene: 5-HT2A / 1269329
• VectorBaseID: AGAMI1_010455
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 783
• Identity: 181/783 - (23%)
• Similarity: 283/783 - (36%)
• Gaps: 250/783 - (31%)

  Fly    88 ALKPPPTDVNTTTTTAGSPLATAALAAAAASASVAAAAARITAKAAHRALTTKQDATSSPASSPA 152
            |.:|.|...:.|......|:.:..|.....|.....||..:....|...:              :
Mosquito   202 AERPTPAQPSQTARAVPGPVQSVRLVCGNVSTESPLAAGSLFESDAFELV--------------S 252

  Fly   153 LQLIDMDNNYTNVAVGLGAMLLNDTLL----------LEG-NDSSLFGEMLANRSGQLDLINGTG 206
            :.|::....:.||.  |...|::.|.|          |.| |.:.|.||:.|            |
Mosquito   253 VSLLEPIQCWMNVE--LRNALVSPTWLNGAEHHAVAALAGWNQTQLLGELPA------------G 303

  Fly   207 GLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVA 271
            |            .|...|...:.:.:.|.|....:||:.|..|:.|:|.||||.||.:.|||:|
Mosquito   304 G------------DTAPGRYEWSFLFVILFIFAGGLGNILVCLAVALDRKLQNVTNYFLLSLAIA 356

  Fly   272 DLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIH 335
            ||.|:..||||||:......|..|...|:|:.:||||.|:|||||:..|::.||..:.| :...|
Mosquito   357 DLLVSLFVMPLGAIPGFLGYWPFGVTWCNIYVTCDVLACSASILHMCFISLGRYLGIRNPLGSRH 421

  Fly   336 SRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCM------VSQDVSYQVFATCCT 394
            ..|.....:.|..||..|::||       .....|..|.|...|      |..:.::.||.:...
Mosquito   422 HSTKRLTGIKIALVWLLAMLVS-------SSITVLGMINQNNIMPGPNECVINNRAFFVFGSLVA 479

  Fly   395 FYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRL-GRFSTAK 458
            ||:|:::::..|....|..||:          |......|:|      :|.|   || ||.:::|
Mosquito   480 FYIPMVMMVVTYALTVQLLRKK----------ARFLEQHPEG------ELFR---RLGGRLASSK 525

  Fly   459 SKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVS 523
            ....|.               .||:||:. ..||..:|:.:|
Mosquito   526 HSNNSQ---------------SDGSSTSN-KAVEMRKFTVNN----------------------- 551

  Fly   524 HLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAM 588
                                            .::|.:|:.:                ::..|::
Mosquito   552 --------------------------------NKQPAYGQHD----------------SSPPSSL 568

  Fly   589 TAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQT 653
            .:.....|....:.:|                                    ||
Mosquito   569 PSVAAGHSALPWRWHG------------------------------------TT----------- 586

  Fly   654 PTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPST-PEPRSRQPTTPQQQPHQQAHQQ 717
                      |..|.|.::.|::.. :.|||..|.:|....| ...|||.......|......::
Mosquito   587 ----------AGTGKMDSRMSSIKG-SMSHPHLGYSNGGNRTMAGKRSRTVCDQGTQTPDSIERE 640

  Fly   718 QQQQQ------QLSSIANPMQKVN------KRKETLEAK---RERKAAKTLAIITGAFVVCWLPF 767
            .::|:      .|:|:..|....|      |::..|.|.   .|:||.|.|.::...||.||.||
Mosquito   641 TRRQKFCSFRIHLNSVPTPAINFNLKFLGSKKRTNLSANAVATEQKATKVLGLVFFTFVFCWAPF 705

  Fly   768 FVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL----FGGHRPVH 828
            |::.:........::.:.:.|:.|||||.:||:||:|||||:..||.||.|:|    ....||..
Mosquito   706 FILNIIFAAWPEAKVPERIVSICLWLGYVSSTINPIIYTIFNKTFRAAFIRLLRCRCERSGRPPR 770

  Fly   829 YRS 831
            |||
Mosquito   771 YRS 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	65/192 (34%)
		TM helix 1	228..254	CDD:320454	6/25 (24%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	15/29 (52%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	6/28 (21%)
		7tm_GPCRs	<743..816	CDD:475119	30/75 (40%)
		TM helix 6	750..772	CDD:410628	9/21 (43%)
		TM helix 7	784..809	CDD:410628	14/24 (58%)
5-HT2A	XP_061500179.1	None