DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and Adra2a

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_031443.4 Gene:Adra2a / 11551 MGIID:87934 Length:465 Species:Mus musculus


Alignment Length:648 Identity:164/648 - (25%)
Similarity:239/648 - (36%) Gaps:240/648 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 NGT----GGLNVTTSKVAEDDFTQLLRMAVTSV-LLGLMILVTIIGNVFVIAAIILERNLQNVAN 262
            |||    ||...|...         |::.:|.| |.||::|.|:.|||.||.|:...|.|:...|
Mouse    29 NGTEAPGGGTRATPYS---------LQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQN 84

  Fly   263 YLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWA 327
            ..:.|||.||:.||.||:|.....|:...|..|...|:|:.:.|||.||:||:||.||::||||:
Mouse    85 LFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWS 149

  Fly   328 VTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQF--------GWKDPDYLQRIEQQKCMVSQD 383
            :|. |:|...||..|:..:|..||..:.::|..|..        |.:.|      .:..|.::..
Mouse   150 ITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQP------AEPSCKINDQ 208

  Fly   384 VSYQVFATCCTFYVPLLVILALYWKIYQTARKRIH----RRRPRPVDAAVNNNQPDGGAATDTKL 444
            ..|.:.::..:|:.|.|:::.:|.:|||.|::|..    ||.|   ||.   :.|.|||  |.:.
Mouse   209 KWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGP---DAC---SAPPGGA--DRRP 265

  Fly   445 HRLRLRLGRFSTA------KSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDS 503
            :.|....|...|.      .::...|.|...||      |..||::.       |.|.|||:..:
Mouse   266 NGLGPERGAGPTGAEAEPLPTQLNGAPGEPAPA------GPRDGDAL-------DLEESSSSEHA 317

  Fly   504 KSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDRE 568
                  |.|                                   |..|:.|.|.|.:...:..:.
Mouse   318 ------ERP-----------------------------------PGPRRPDRGPRAKGKTRASQV 341

  Fly   569 ELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGG 633
            :..|...:.||    ..:...|:|:...|::                                ||
Mouse   342 KPGDSLPRRGP----GAAGPGASGSGHGEER--------------------------------GG 370

  Fly   634 GASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEP 698
            ||..|..                                                          
Mouse   371 GAKASRW---------------------------------------------------------- 377

  Fly   699 RSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVC 763
            |.||                                         .||::....||::.|.||||
Mouse   378 RGRQ-----------------------------------------NREKRFTFVLAVVIGVFVVC 401

  Fly   764 WLPFFVMALTMPLCA-ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHR 825
            |.|||   .|..|.| .|.:...:.:.|.|.||.||:|||||||||:.:||:|||:||..|.|
Mouse   402 WFPFF---FTYTLIAVGCPVPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDR 461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 68/195 (35%)
TM helix 1 228..254 CDD:320454 13/26 (50%)
TM helix 2 261..287 CDD:320454 11/25 (44%)
TM helix 3 299..329 CDD:320454 17/29 (59%)
TM helix 4 340..362 CDD:320454 6/21 (29%)
TM helix 5 383..412 CDD:320454 7/28 (25%)
7tm_GPCRs <743..816 CDD:475119 34/73 (47%)
TM helix 6 750..772 CDD:410628 11/21 (52%)
TM helix 7 784..809 CDD:410628 14/24 (58%)
Adra2aNP_031443.4 7tmA_alpha2A_AR 49..452 CDD:320445 150/608 (25%)
TM helix 1 50..76 CDD:320445 13/25 (52%)
TM helix 2 83..109 CDD:320445 11/25 (44%)
TM helix 3 121..151 CDD:320445 17/29 (59%)
TM helix 4 163..186 CDD:320445 6/22 (27%)
TM helix 5 208..237 CDD:320445 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..378 43/291 (15%)
TM helix 6 382..412 CDD:320445 14/32 (44%)
TM helix 7 420..445 CDD:320445 14/24 (58%)

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