Protein Alignment 5-HT1A and Adra1a

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_038489.2
• Gene: Adra1a / 11549
• MGIID: 104773
• Length: 466
• Species: Mus musculus
• Alignment Length: 624
• Identity: 124/624 - (19%)
• Similarity: 201/624 - (32%)
• Gaps: 295/624 - (47%)

  Fly   203 NGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVAS 267
            |.:.|.|.|.....    ..:.:..:..|:||.:|:..::||:.||.::...|:|.:|.:|.:.:
Mouse     7 NASEGSNCTHPPAQ----VNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVN 67

  Fly   268 LAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NI 331
            ||||||.:...|:|..|::||...|..|...|:||.:.|||||||||:.|..|::|||..|: .:
Mouse    68 LAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPL 132

  Fly   332 DYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKD--PDYLQRIEQQKCMVSQDVSYQVFATCCT 394
            .|....|..|....:.|||..::::|:.|.|||:.  |:     ::..|.::::..|.:|:...:
Mouse   133 RYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPE-----DETICQINEEPGYVLFSALGS 192

  Fly   395 FYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKS 459
            |||||.:||.:|.::|..|     :|..|.:.:.:..::.|....| .::||
Mouse   193 FYVPLTIILVMYCRVYVVA-----KRESRGLKSGLKTDKSDSEQVT-LRIHR------------- 238

  Fly   460 KTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSH 524
                                                                             
Mouse   239 ----------------------------------------------------------------- 238

  Fly   525 LVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMT 589
                                                                             
Mouse   239 ----------------------------------------------------------------- 238

  Fly   590 AAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTP 654
                                               |:|.:.|.|.:|..|.|..:
Mouse   239 -----------------------------------KNVPAEGSGVSSAKNKTHFS---------- 258

  Fly   655 TSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQ 719
                                                                             
Mouse   259 ----------------------------------------------------------------- 258

  Fly   720 QQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA---ACQ 781
                              ...|:..||:||||||.|:.|.||:||||||   |.||:.:   ..:
Mouse   259 ------------------VRLLKFSREKKAAKTLGIVVGCFVLCWLPFF---LVMPIGSFFPNFK 302

  Fly   782 ISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ..::|..:..||||.||.:||:||...|.||::||:.:|
Mouse   303 PPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	67/188 (36%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	10/25 (40%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:475119	35/75 (47%)
		TM helix 6	750..772	CDD:410628	14/21 (67%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
Adra1a	NP_038489.2	7tmA_alpha1A_AR	27..337	CDD:320448	117/594 (20%)
		TM helix 1	28..54	CDD:320448	8/25 (32%)
		TM helix 2	61..87	CDD:320448	10/25 (40%)
		TM helix 3	99..129	CDD:320448	17/29 (59%)
		TM helix 4	141..164	CDD:320448	6/22 (27%)
		TM helix 5	181..210	CDD:320448	11/28 (39%)
		TM helix 6	265..295	CDD:320448	21/32 (66%)
		TM helix 7	305..330	CDD:320448	11/24 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		3/8 (38%)