DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT1A and or90h3

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_009300995.1	Gene:	or90h3 / 103911276	ZFINID:	ZDB-GENE-081104-20	Length:	309	Species:	Danio rerio

Alignment Length:	275	Identity:	52/275 - (18%)
Similarity:	106/275 - (38%)	Gaps:	73/275 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 LNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAI---ILERNLQNVANYLVASLA 269
            :|.|...|  |.:.:.|...:..|.||  .::.:|..:.|:...   :..|:.:.:   |...|.
Zfish     1 MNTTVWIV--DSYEEALAKNIVIVSLG--FIINVINGMLVLTFFSNPMFSRDSRYI---LYIHLV 58

  Fly   270 VADLFVACLVMPLGAVYEISQGW-ILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDY 333
            :.|:.:.|:.:.|   |.::... ::...||.|......:....:.|:|..:|::|:.|:....|
Zfish    59 INDMLMICVSVIL---YVLTYAAPVVNVSLCYILMILGKVFFMITPLNLAGMAIERFIAICKPLY 120

  Fly   334 IHSR--TSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVS-YQVFATCCTF 395
             ||:  |..|.:..|..:|....|.|:              :.....:|:|.:| ::.|..|...
Zfish   121 -HSQICTPQRTYFFICFLWCLGAISSM--------------VNIIISLVTQPLSFFRSFIFCYPT 170

  Fly   396 YV------------PLLVILALYW--------KIYQTARKRIHRRRPRPVDAAVNNNQPDGGAAT 440
            |:            .|::.:::.|        ::..||||.:.:                 |:|.
Zfish   171 YMFPSKAHDDHYTASLVIYMSVVWIIICYTYCRVIFTARKAVSK-----------------GSAN 218

  Fly   441 DTK----LHRLRLRL 451
            ..:    ||.::|.|
Zfish   219 KARNTILLHGVQLLL 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	37/212 (17%)
		TM helix 1	228..254	CDD:320454	5/28 (18%)
		TM helix 2	261..287	CDD:320454	5/25 (20%)
		TM helix 3	299..329	CDD:320454	7/29 (24%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	6/49 (12%)
		7tm_GPCRs	<743..816	CDD:355774
		TM helix 6	747..772	CDD:341315
		TM helix 7	784..809	CDD:341315
or90h3	XP_009300995.1	7tm_4	19..>143	CDD:304433	27/132 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100