Protein Alignment 5-HT1A and or90h3

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_073761990.1
• Gene: or90h3 / 103911276
• ZFINID: ZDB-GENE-081104-20
• Length: 309
• Species: Danio rerio
• Alignment Length: 275
• Identity: 52/275 - (18%)
• Similarity: 106/275 - (38%)
• Gaps: 73/275 - (26%)

  Fly   208 LNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAI---ILERNLQNVANYLVASLA 269
            :|.|...|  |.:.:.|...:..|.||  .::.:|..:.|:...   :..|:.:.:   |...|.
Zfish     1 MNTTVWIV--DSYEEALAKNIVIVSLG--FIINVINGMLVLTFFSNPMFSRDSRYI---LYIHLV 58

  Fly   270 VADLFVACLVMPLGAVYEISQGW-ILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDY 333
            :.|:.:.|:.:.|   |.::... ::...||.|......:....:.|:|..:|::|:.|:....|
Zfish    59 INDMLMICVSVIL---YVLTYAAPVVNASLCYILMILGKVFFMITPLNLAGMAIERFIAICKPLY 120

  Fly   334 IHSR--TSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVS-YQVFATCCTF 395
             ||:  |..|.:..|..:|....|.|:              :.....:|:|.:| ::.|..|...
Zfish   121 -HSQICTPQRTYFFICFLWCLGAISSM--------------VNIIISLVTQPLSFFRSFIFCYPT 170

  Fly   396 YV------------PLLVILALYW--------KIYQTARKRIHRRRPRPVDAAVNNNQPDGGAAT 440
            |:            .|::.:::.|        ::..||||.:.:                 |:|.
Zfish   171 YMFPSKAHDDHYTASLVIYMSVVWIIISYTYCRVIFTARKAVSK-----------------GSAN 218

  Fly   441 DTK----LHRLRLRL 451
            ..:    ||.::|.|
Zfish   219 KARNTILLHGVQLLL 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	37/212 (17%)
		TM helix 1	228..254	CDD:320454	5/28 (18%)
		TM helix 2	261..287	CDD:320454	5/25 (20%)
		TM helix 3	299..329	CDD:320454	7/29 (24%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	6/49 (12%)
		7tm_GPCRs	<743..816	CDD:475119
		TM helix 6	750..772	CDD:410628
		TM helix 7	784..809	CDD:410628
or90h3	XP_073761990.1	None