Protein Alignment 5-HT1A and htr4

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_009289337.1
• Gene: htr4 / 101882850
• ZFINID: ZDB-GENE-160114-31
• Length: 423
• Species: Danio rerio
• Alignment Length: 670
• Identity: 134/670 - (20%)
• Similarity: 201/670 - (30%)
• Gaps: 342/670 - (51%)

  Fly   188 FGEMLANRSGQLDLINGTGGLNVTTS-------KVAEDDFTQLLRMAVTSVLLGLMILVTIIGNV 245
            |.....:|:|.|.:   .|.:|::::       :|..::...|.:.......|.|::|::::||:
Zfish    17 FDPRAPHRNGPLRI---DGYMNLSSTGQMPEMEEVDTNESNGLAKRVALISFLSLVMLMSVLGNL 78

  Fly   246 FVIAAIILERNLQNV-ANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLC 309
            .|:.|:..:|.|:.: .||.:.|||.|||.|:.||||.||:..|.|.||.|...|.:.||.|||.
Zfish    79 LVMVAVCKDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELIHQNWIYGETFCLVRTSLDVLL 143

  Fly   310 CTASILHLVAIAVDRYWAV--TNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAP-QFGWKDPDYLQ 371
            .|||||||..|::|||:|:  ..:.|.:..|..||.:||...|....::|..| ..||.......
Zfish   144 TTASILHLCCISLDRYYAICCQPLVYRNKMTPLRVTLMIGGCWIIPTVISFLPIMQGWNSIGIKD 208

  Fly   372 RIEQQK-------CMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAV 429
            .|:::|       |:...:..|.:..:...||:||::::..|.:||.|||
Zfish   209 LIDKRKISGNSTVCVFMVNKPYALTCSVVAFYLPLVLMVLAYQRIYVTAR--------------- 258

  Fly   430 NNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDT 494
                                                                             
Zfish   259 ----------------------------------------------------------------- 258

  Fly   495 EFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRP 559
                                                                             
Zfish   259 ----------------------------------------------------------------- 258

  Fly   560 EHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQ 624
            ||.                                                       .|:..||
Zfish   259 EHA-------------------------------------------------------RQISMLQ 268

  Fly   625 KSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTA 689
               ::||.|.|.:::
Zfish   269 ---RAGGAGNADSAD-------------------------------------------------- 280

  Fly   690 NESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLA 754
                                 ||:.|:.                          :.|.||||||.
Zfish   281 ---------------------HQRNHRM--------------------------RTETKAAKTLC 298

  Fly   755 IITGAFVVCWLPFFVMALTMP---------LCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSP 810
            ||.|.|.:||.|||:..:..|         |.|||          |||||.||.|||::|...:.
Zfish   299 IIMGCFCLCWAPFFITNVVDPFIDYSVPEQLWAAC----------LWLGYINSMLNPILYAFLNK 353

  Fly   811 EFRQAFKRILFGGHRPVHYR 830
            .||:||..||..||:  .||
Zfish   354 SFRRAFLIILCCGHK--RYR 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	69/196 (35%)
		TM helix 1	228..254	CDD:320454	7/25 (28%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	18/31 (58%)
		TM helix 4	340..362	CDD:320454	7/22 (32%)
		TM helix 5	383..412	CDD:320454	8/28 (29%)
		7tm_GPCRs	<743..816	CDD:475119	34/81 (42%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
htr4	XP_009289337.1	7tmA_5-HT4	60..359	CDD:320184	118/608 (19%)
		TM helix 1	61..87	CDD:320184	7/25 (28%)
		TM helix 2	95..121	CDD:320184	15/25 (60%)
		TM helix 3	133..163	CDD:320184	18/29 (62%)
		TM helix 4	176..199	CDD:320184	7/22 (32%)
		TM helix 5	227..256	CDD:320184	8/28 (29%)
		TM helix 6	288..318	CDD:320184	16/29 (55%)
		TM helix 7	327..352	CDD:320184	15/34 (44%)