DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and htr1b

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_002936251.2	Gene:	htr1b / 100495915	XenbaseID:	XB-GENE-988006	Length:	385	Species:	Xenopus tropicalis

Alignment Length:	619	Identity:	149/619 - (24%)
Similarity:	224/619 - (36%)	Gaps:	270/619 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 GLNVTTS--KVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLA 269
            |.:..||  ...::|.....::.:| |:|.|:.|.|::.|.|||..:...|.|...||||:||||
Frog    25 GRSCITSLDSYGQEDVLSFSKIILT-VILALITLATLLSNAFVITTVYQTRKLHTPANYLIASLA 88

  Fly   270 VADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDY 333
            ..||.|:.||:|:..||.::..|.||..:||:|.|.|:.|||||||||..||:|||||:|: ::|
Frog    89 FTDLLVSILVLPIAIVYTVTGKWTLGQIICDMWLSSDITCCTASILHLCVIALDRYWAITDAVEY 153

  Fly   334 IHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQD-VSYQVFATCCTFYV 397
            ...||..|..:||..||..::.:|:.|.| |:..   :..|...|.|:.| :.|.|::|...||:
Frog   154 TKKRTPKRAVVMIALVWVFSISISMPPLF-WRQS---KAEEIAVCAVNTDHILYTVYSTVGAFYI 214

  Fly   398 PLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTG 462
            |.|:::|||.:||..||.||.::.|:                               :|.|..|.
Frog   215 PTLLLIALYGRIYVEARSRILKQSPK-------------------------------TTGKRLTK 248

  Fly   463 SAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVA 527
            :.:....|                          .||:|.|.:...:|.||.:|:.:
Frog   249 AHLITDSP--------------------------GSSSVSSTNSRTLEMPSDAGSPV-------- 279

  Fly   528 LAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAG 592

Frog   280 ----------------------------------------------------------------- 279

  Fly   593 TNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQ 657
                                   .|.||:             ...|:|..
Frog   280 -----------------------YLNQVK-------------VKVSDALL--------------- 293

  Fly   658 GVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQ 722

Frog   294 ----------------------------------------------------------------- 293

  Fly   723 QLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA-ACQISDSV 786
                          .|:.:.|.|||||.|||.:|.||::|||||||:::|.||:|. ||....::
Frog   294 --------------EKKKIMAARERKATKTLGVILGAYIVCWLPFFIISLVMPICKDACWFHPAI 344

  Fly   787 ASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ...|.||||.||.:||:|||:.:.:|:|||.:::
Frog   345 FDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLI 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	81/187 (43%)
		TM helix 1	228..254	CDD:320454	10/25 (40%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	21/29 (72%)
		TM helix 4	340..362	CDD:320454	7/21 (33%)
		TM helix 5	383..412	CDD:320454	13/29 (45%)
		7tm_GPCRs	<743..816	CDD:355774	39/73 (53%)
		TM helix 6	747..772	CDD:341315	16/24 (67%)
		TM helix 7	784..809	CDD:341315	12/24 (50%)
htr1b	XP_002936251.2	7tmA_5-HT1B_1D	42..374	CDD:320455	143/596 (24%)
		TM helix 1	47..73	CDD:320455	10/26 (38%)
		TM helix 2	80..106	CDD:320455	15/25 (60%)
		TM helix 3	118..148	CDD:320455	21/29 (72%)
		TM helix 4	160..183	CDD:320455	8/23 (35%)
		TM helix 5	200..229	CDD:320455	12/28 (43%)
		TM helix 6	301..331	CDD:320455	19/29 (66%)
		TM helix 7	342..367	CDD:320455	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920