Protein Alignment 5-HT1A and htr1f

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_002931817.1
• Gene: htr1f / 100494586
• XenbaseID: XB-GENE-1010473
• Length: 360
• Species: Xenopus tropicalis
• Alignment Length: 631
• Identity: 152/631 - (24%)
• Similarity: 232/631 - (36%)
• Gaps: 286/631 - (45%)

  Fly   209 NVT----TSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLA 269
            |:|    ||:..:...|..:.:::|   |.::.|:|...|..||||||:.|.|.:.||||:.|||
 Frog     5 NLTDYNCTSEHLQKGITPKILISLT---LSILTLMTTAINSLVIAAIIVTRKLHHPANYLICSLA 66

  Fly   270 VADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDY 333
            |.|..||.||||...:|.:.:.||:|..:||||.|.|:.|||.|||||.|||:|||.|:|: ::|
 Frog    67 VTDFLVAVLVMPFSIMYIMKETWIMGQAICDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEY 131

  Fly   334 IHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRI-EQQKCMVSQD-VSYQVFATCCTFY 396
            ...||......||..||..::.:|:.|.| |:.    |.: ::.:|::..| :.:.:::|...||
 Frog   132 ARKRTPKHAAFMIAVVWIISIFISMPPLF-WRH----QALNKEDECIIKHDHIVFTIYSTFGAFY 191

  Fly   397 VPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKT 461
            :||.:||.||:|||:.|:...|:|
 Frog   192 IPLALILILYYKIYKAAKTLYHKR----------------------------------------- 215

  Fly   462 GSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLV 526
                                     :|:.||
 Frog   216 -------------------------SVSRVE---------------------------------- 221

  Fly   527 ALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAA 591
                                     :|.:||
 Frog   222 -------------------------REQNGQ---------------------------------- 227

  Fly   592 GTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTS 656
                           ||.|                             |||...|:
 Frog   228 ---------------VLLD-----------------------------ATTTLCIA--------- 239

  Fly   657 QGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPH---QQAHQQQ 718
                                                    |......:|...:.|   :.|..:.
 Frog   240 ----------------------------------------EKSFSDHSTDFDKIHITVRNARVEM 264

  Fly   719 QQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQIS 783
            :|::..            ||:.:.:.||||||.||.:|.||||:|||||||..:.:.:|.:|.||
 Frog   265 KQEKAY------------RKQKISSTRERKAATTLGLILGAFVICWLPFFVKEVIVNICESCYIS 317

  Fly   784 DSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHY 829
            |.:::...||||.||.:||:|||||:.:|::||::::    |..||
 Frog   318 DDMSNFLTWLGYLNSLINPLIYTIFNEDFKKAFQKLM----RCRHY 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	80/188 (43%)
		TM helix 1	228..254	CDD:320454	11/25 (44%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	21/29 (72%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	13/29 (45%)
		7tm_GPCRs	<743..816	CDD:475119	39/72 (54%)
		TM helix 6	750..772	CDD:410628	15/21 (71%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
htr1f	XP_002931817.1	7tmA_5-HT1F	24..351	CDD:320456	143/598 (24%)
		TM helix 1	25..51	CDD:320456	11/28 (39%)
		TM helix 2	58..84	CDD:320456	15/25 (60%)
		TM helix 3	96..126	CDD:320456	21/29 (72%)
		TM helix 4	138..160	CDD:320456	6/21 (29%)
		TM helix 5	178..207	CDD:320456	12/28 (43%)
		TM helix 6	278..308	CDD:320456	20/29 (69%)
		TM helix 7	318..343	CDD:320456	13/24 (54%)