Protein Alignment 5-HT1A and adra1a

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_002933012.2
• Gene: adra1a / 100492776
• XenbaseID: XB-GENE-6048410
• Length: 489
• Species: Xenopus tropicalis
• Alignment Length: 695
• Identity: 154/695 - (22%)
• Similarity: 227/695 - (32%)
• Gaps: 330/695 - (47%)

  Fly   159 DNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQL 223
            ||.|...:    |:.....:|.|.|         ...|.||.|.....|..:..||.
 Frog     7 DNIYARSS----AISFTMVILYENN---------TVESIQLCLNCTHPGATINISKA-------- 50

  Fly   224 LRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI 288
               .|..|:.|:.|...::||:.||.::...|:||.|.:|.:|:||||||.:..:|:|..|.:||
 Frog    51 ---IVVGVIFGVFITFGVLGNILVILSVACHRHLQTVTHYFIANLAVADLLLMSMVLPFSATFEI 112

  Fly   289 SQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVFMMIFCVWTA 352
            ...|:.|...|:||.:.|||||||||:.|.||::|||..|: .:.|....|..|..:.:.|:|..
 Frog   113 QGYWLFGRIFCNIWAAVDVLCCTASIMSLCAISIDRYIGVSYPLRYPSIMTEKRGVLALLCIWVL 177

  Fly   353 AVIVSLAPQFGWKDPDYLQRIEQQK-CMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKR 416
            ::::|:.|.||||.|    ..|..| |.::::..|.:|:...:||:||.:||.:|:::|..|::
 Frog   178 SLVISIGPLFGWKQP----APEDDKICEITKEPGYALFSAFGSFYLPLSIILVMYFRVYIVAKR- 237

  Fly   417 IHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVD 481
                                                     :||.
 Frog   238 -----------------------------------------ESKV-------------------- 241

  Fly   482 GNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGM 546
                                           .|||.::
 Frog   242 -------------------------------LTSGMKL--------------------------- 248

  Fly   547 APSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDP 611
                            |:.|.||:
 Frog   249 ----------------EKSDSEEV----------------------------------------- 256

  Fly   612 QLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTL 676
                                                                           ||
 Frog   257 ---------------------------------------------------------------TL 258

  Fly   677 TSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETL 741
                                  |..:.:||               :.:.|.::..||.......|
 Frog   259 ----------------------RIHRKSTP---------------ESIGSTSSSKQKTQFSVRLL 286

  Fly   742 EAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA---ACQISDSVASLFLWLGYFNSTLNPV 803
            :..||:||||||.|:.|.||:||||||   |.||:.:   ....||::..:..|||||||.:|||
 Frog   287 KFSREKKAAKTLGIVVGCFVLCWLPFF---LVMPIGSIYPPANSSDTIFKITFWLGYFNSCINPV 348

  Fly   804 IYTIFSPEFRQAFKRILFG--GHR---------------PVHYRS 831
            ||...|||||:||:.||..  .||               |||..|
 Frog   349 IYPCSSPEFRKAFQNILHARCSHRRQAASKYSSGFLLNSPVHRSS 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	71/187 (38%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	10/28 (36%)
		7tm_GPCRs	<743..816	CDD:475119	40/75 (53%)
		TM helix 6	750..772	CDD:410628	14/21 (67%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
adra1a	XP_002933012.2	7tmA_alpha1A_AR	51..361	CDD:320448	130/593 (22%)
		TM helix 1	52..78	CDD:320448	8/25 (32%)
		TM helix 2	85..111	CDD:320448	11/25 (44%)
		TM helix 3	123..153	CDD:320448	18/29 (62%)
		TM helix 4	165..188	CDD:320448	5/22 (23%)
		TM helix 5	205..234	CDD:320448	10/28 (36%)
		TM helix 6	289..319	CDD:320448	21/32 (66%)
		TM helix 7	329..354	CDD:320448	13/24 (54%)