DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1A and htr1a

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_004910432.2	Gene:	htr1a / 100488829	XenbaseID:	XB-GENE-984750	Length:	411	Species:	Xenopus tropicalis

Alignment Length:	637	Identity:	175/637 - (27%)
Similarity:	242/637 - (37%)	Gaps:	248/637 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 LDLINGTGGLNVT--TSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVA 261
            :|.:|.|...:.|  |..|.|.:...|....|||:.||.:||..|.||..|||||.|||.||.||
Frog     1 MDALNNTTSSDHTPETGNVTEPEEVALSYQIVTSLFLGTLILCAIFGNACVIAAIALERCLQTVA 65

  Fly   262 NYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYW 326
            |||:.||||.||.|:.||:|:.|..::...|.||...|||:.|.||||||:|||||.|||:||||
Frog    66 NYLIGSLAVTDLMVSVLVLPMAAHNQVLNKWTLGQVTCDIFISLDVLCCTSSILHLCAIALDRYW 130

  Fly   327 AVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFA 390
            |:|: |||::.||..|..::|...|.....:|:.|..||:.|:  .|.:...|.:|:|..|.:::
Frog   131 AITDPIDYVNKRTPRRAAVLISITWIVGFSISIPPMLGWRTPE--DRSDPNACKISEDPGYTIYS 193

  Fly   391 TCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFS 455
            |...||:||:::|.||.||::.||.||.:
Frog   194 TFGAFYIPLILMLVLYGKIFKAARFRIRK------------------------------------ 222

  Fly   456 TAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIA 520
                                           ||...|..:.:.:                   ..
Frog   223 -------------------------------TVKKAEKKKVADT-------------------CL 237

  Fly   521 TVSHLVALAKQQGKST--------AKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQV 577
            :||..||..|..|:.:        .|.||.|||..            .|||          |..|
Frog   238 SVSPAVAERKSNGEPSKNWKRTVEPKPSACVNGAI------------RHGE----------DGAV 280

  Fly   578 GPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATT 642
                                       :|::|             :...|.|
Frog   281 ---------------------------LEIIE-------------VHHYVNS------------- 292

  Fly   643 ITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQ 707
                                          .|.|...|.:|.:
Frog   293 ------------------------------KSHLDLPNHAHDM---------------------- 305

  Fly   708 QQPHQQAHQQQQQQQQLSSIANPMQKVNKR----KETLEAKRERKAAKTLAIITGAFVVCWLPFF 768
                              ::|...:|.|.|    |..:...||||..|||.||.|.|:.||||||
Frog   306 ------------------AVAPCSEKRNDRATDAKRKVALARERKTVKTLGIIMGTFIFCWLPFF 352

  Fly   769 VMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ::||.:|.|..|.:...:..:..||||.||.|||:||..|:.:|:.|||:|:
Frog   353 IVALVLPFCETCHMPHLLFDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKII 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	91/186 (49%)
		TM helix 1	228..254	CDD:320454	15/25 (60%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	23/29 (79%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	12/28 (43%)
		7tm_GPCRs	<743..816	CDD:355774	35/72 (49%)
		TM helix 6	747..772	CDD:341315	15/24 (63%)
		TM helix 7	784..809	CDD:341315	11/24 (46%)
htr1a	XP_004910432.2	7tmA_5-HT1A_vertebrates	31..400	CDD:320453	163/601 (27%)
		TM helix 1	33..57	CDD:320453	14/23 (61%)
		TM helix 2	66..88	CDD:320453	13/21 (62%)
		TM helix 3	104..126	CDD:320453	16/21 (76%)
		TM helix 4	149..165	CDD:320453	3/15 (20%)
		TM helix 5	187..210	CDD:320453	8/22 (36%)
		TM helix 6	334..356	CDD:320453	13/21 (62%)
		TM helix 7	368..393	CDD:320453	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20148
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2699
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X366
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060