Protein Alignment 5-HT1A and taar1

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_002935857.1
• Gene: taar1 / 100487786
• XenbaseID: XB-GENE-961114
• Length: 339
• Species: Xenopus tropicalis
• Alignment Length: 601
• Identity: 109/601 - (18%)
• Similarity: 157/601 - (26%)
• Gaps: 326/601 - (54%)

  Fly   237 ILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDI 301
            ||.|::||:.||.:|...:.|....|||:.|::..|..:...|||...|..:...|..|...|.:
 Frog    35 ILATVVGNLAVIISIAHFKQLHTPTNYLILSMSTVDFLLGSCVMPYSMVRSVENCWYFGDLFCKV 99

  Fly   302 WTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVF---MMIFCVWTAAVIVSLAPQF- 362
            .||.|::..|:||.||..|:||||:||  .|.:..:|...||   :||...|....|.:....|
 Frog   100 HTSTDIMLSTSSIFHLSFISVDRYFAV--CDPLRYKTKMNVFSVSLMIVTSWVVPTIFAFTMVFL 162

  Fly   363 -----GWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRP 422
                 |.:...|.|......|.|....:..:.|:..:||:|..|:|.:|.|||..||::
 Frog   163 ELNIKGTESYYYNQVSCFGGCAVFFSQTSGLVASMVSFYIPGFVMLCVYGKIYVIARRQ------ 221

  Fly   423 RPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNT 487
                                                                             
 Frog   222 ----------------------------------------------------------------- 221

  Fly   488 VNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQ 552
                                                                             
 Frog   222 ----------------------------------------------------------------- 221

  Fly   553 EDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQL 617
                                                                             
 Frog   222 ----------------------------------------------------------------- 221

  Fly   618 EQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQS 682
                  .:|:|.
 Frog   222 ------ARSIKD----------------------------------------------------- 227

  Fly   683 HPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRER 747
                 :||:.|.                            |::...|  |.|::       .|:|
 Frog   228 -----SANQMPF----------------------------QITLGVN--QHVSR-------SRDR 250

  Fly   748 KAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQ------ISDSVASLFLWLGYFNSTLNPVIYT 806
            ||||||.||.|.|::||.|||       .|.|..      |...|...|:|:||.|||.||::|.
 Frog   251 KAAKTLGIIMGVFLICWTPFF-------FCTATDGFINYVIPPIVIDAFVWIGYLNSTFNPMVYA 308

  Fly   807 IFSPEFRQAFKRILFG 822
            .|...|::|.:.||||
 Frog   309 FFYLWFQRALRMILFG 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	60/184 (33%)
		TM helix 1	228..254	CDD:320454	8/16 (50%)
		TM helix 2	261..287	CDD:320454	9/25 (36%)
		TM helix 3	299..329	CDD:320454	15/29 (52%)
		TM helix 4	340..362	CDD:320454	6/24 (25%)
		TM helix 5	383..412	CDD:320454	10/28 (36%)
		7tm_GPCRs	<743..816	CDD:475119	33/78 (42%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
taar1	XP_002935857.1	7tmA_TAAR1	25..318	CDD:320438	104/593 (18%)
		TM helix 1	26..52	CDD:320438	8/16 (50%)
		TM helix 2	59..85	CDD:320438	9/25 (36%)
		TM helix 3	97..127	CDD:320438	16/31 (52%)
		TM helix 4	139..162	CDD:320438	5/22 (23%)
		TM helix 5	188..217	CDD:320438	10/28 (36%)
		TM helix 6	247..277	CDD:320438	19/36 (53%)
		TM helix 7	286..311	CDD:320438	11/24 (46%)