DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and adra2b

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:XP_002932610.1 Gene:adra2b / 100485811 XenbaseID:XB-GENE-999343 Length:410 Species:Xenopus tropicalis


Alignment Length:597 Identity:148/597 - (24%)
Similarity:229/597 - (38%) Gaps:211/597 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 AVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG 291
            ||.:.::..::|.||.|||.||.|::..|:|:...|..:.|||.||:.||.|::|.....|:...
 Frog    13 AVIAAIITFLVLFTIFGNVLVIIAVLTSRSLKAPQNLFLVSLAAADILVATLIIPFSLANELMGY 77

  Fly   292 WILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVI 355
            |..|...|:::.:.|||.||:||:||.||::||||:|:. |:|...||..|:..:|..|||.|.:
 Frog    78 WYFGKTWCEMYLALDVLFCTSSIVHLCAISLDRYWSVSQAIEYNSKRTPKRIKCIILIVWTLAAL 142

  Fly   356 VSLAPQ-FGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHR 419
            :||.|. :..|..|...:.|   |.::::..|.:.::.|:|:.|.|:::.:|.:||..|::|..:
 Frog   143 ISLPPLIYKGKSKDQNAKPE---CKLNEEPWYILSSSICSFFAPCLIMILVYLRIYLIAKRRNRK 204

  Fly   420 RRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNS 484
            .                  :||.||.::                            |.||....:
 Frog   205 N------------------STDKKLKKM----------------------------APGLFSRTN 223

  Fly   485 TNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPS 549
            .:::|: ..|:.....:.|:.:.|                 :||..........||.        
 Frog   224 KHSLNS-SHTQTQCGIISSQEKTG-----------------LALDDLHCGVPVLSST-------- 262

  Fly   550 GRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQ 614
                             |||.....|..|.||             :.|:....||.|        
 Frog   263 -----------------REERNGHSESFGLQP-------------QGENLKHTNGCE-------- 289

  Fly   615 QQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSC 679
                                            .|:.....|.:||.:.     |..||.|.|:|.
 Frog   290 --------------------------------PAVMDTVATVKGVMLM-----PKGAKDSDLSSA 317

  Fly   680 NQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAK 744
                                                                    |:|..:  .
 Frog   318 --------------------------------------------------------KKKSYI--N 324

  Fly   745 RERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA-ACQISDSVASLFLWLGYFNSTLNPVIYTIF 808
            ||::....||::.|.||:||.|||.......:|. .|.|.|||...|.|:||.||:|||||||||
 Frog   325 REKRFTFVLAVVIGVFVLCWFPFFFTYSLGAICTELCYIPDSVFQFFFWIGYCNSSLNPVIYTIF 389

  Fly   809 SPEFRQAFKRIL 820
            :.:||:||:|||
 Frog   390 NQDFRKAFRRIL 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 68/187 (36%)
TM helix 1 228..254 CDD:320454 10/25 (40%)
TM helix 2 261..287 CDD:320454 10/25 (40%)
TM helix 3 299..329 CDD:320454 16/29 (55%)
TM helix 4 340..362 CDD:320454 9/22 (41%)
TM helix 5 383..412 CDD:320454 8/28 (29%)
7tm_GPCRs <743..816 CDD:475119 35/73 (48%)
TM helix 6 750..772 CDD:410628 10/21 (48%)
TM helix 7 784..809 CDD:410628 17/24 (71%)
adra2bXP_002932610.1 7tmA_alpha2B_AR 7..397 CDD:320444 143/591 (24%)
TM helix 1 14..40 CDD:320444 10/25 (40%)
TM helix 2 47..73 CDD:320444 10/25 (40%)
TM helix 3 85..115 CDD:320444 16/29 (55%)
TM helix 4 127..150 CDD:320444 9/22 (41%)
TM helix 5 168..197 CDD:320444 8/28 (29%)
TM helix 6 324..354 CDD:320444 12/29 (41%)
TM helix 7 365..390 CDD:320444 17/24 (71%)

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