Protein Alignment 5-HT1A and LOC100330650

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_002663705.4
• Gene: LOC100330650 / 100330650
• -ID: -
• Length: 431
• Species: Danio rerio
• Alignment Length: 599
• Identity: 139/599 - (23%)
• Similarity: 228/599 - (38%)
• Gaps: 200/599 - (33%)

  Fly   227 AVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQG 291
            ||.::.:.|::|.||.||:.||.|::..|:|:...|..:.|||.||:.||.||:|.....|:...
Zfish    19 AVFAITMTLIMLFTIFGNIMVIIAVLTCRSLRGPQNLFLVSLAAADILVATLVIPFSLAKELMGC 83

  Fly   292 WILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVI 355
            |......|:|..:.|||.||:||:||.||::|||.:::. :.|...||..::...|..||..:.|
Zfish    84 WYFESLWCEIILALDVLFCTSSIIHLCAISLDRYLSISRPVQYGTQRTPRKIKGAIVVVWLISAI 148

  Fly   356 VSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRR 420
            :|..|......|...:...:..|.:::|..|.:::|..:|:.|.|:::.:|.:|||.|:|  |.|
Zfish   149 ISFPPLVSMDKPQQAKGDPRTTCELNEDKWYILYSTIGSFFAPCLIMILVYVRIYQIAKK--HTR 211

  Fly   421 RPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNST 485
                        .|.|....|
Zfish   212 ------------CPPGEPRKD-------------------------------------------- 220

  Fly   486 NTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSG 550
                                       ||.|.::           |.||.....||....:|||
Zfish   221 ---------------------------STVGREL-----------QNGKDGGVDSANNPNIAPS- 246

  Fly   551 RQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGT---NESEDQCKANGVEVLEDPQ 612
                                  :.|.|...|....||.....:   .|::::..::|.:|
Zfish   247 ----------------------KSEAVKQPPVITESAQKTKRSRRCKENKEESSSSGSDV----- 284

  Fly   613 LQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLT 677
                         .|..|.....:.||..::.:::....|:.:.:.: ||       |:|.|.|.
Zfish   285 -------------EVVGGHDANGTNSNMASLETVNKTPAQSQSYRNI-IA-------TSKGSQLA 328

  Fly   678 SCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLE 742
            :...:    ||.|                                            .:||..:
Zfish   329 NAKAT----GTPN--------------------------------------------TRRKAMI- 344

  Fly   743 AKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA-ACQISDSVASLFLWLGYFNSTLNPVIYT 806
             .||::....||::.|.|::||.|||.......:|. .|::.:.:.:.|.|:||.||.|||:|||
Zfish   345 -VREKRFTFVLAVVIGVFIICWFPFFFSYSLQAICPDMCKVPEGLFTFFFWIGYCNSALNPLIYT 408

  Fly   807 IFSPEFRQAFKRIL 820
            ||:.:||:|||:||
Zfish   409 IFNRDFRKAFKKIL 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	63/186 (34%)
		TM helix 1	228..254	CDD:320454	10/25 (40%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	16/29 (55%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	9/28 (32%)
		7tm_GPCRs	<743..816	CDD:475119	29/73 (40%)
		TM helix 6	750..772	CDD:410628	9/21 (43%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)
LOC100330650	XP_002663705.4	None