DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT1A and or90d1

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_017212233.1	Gene:	or90d1 / 100151233	ZFINID:	ZDB-GENE-081104-36	Length:	308	Species:	Danio rerio

Alignment Length:	175	Identity:	38/175 - (21%)
Similarity:	72/175 - (41%)	Gaps:	37/175 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 TSVLLGLMILVTIIGNVFVIAAIILERNL--QNVANYLVASLAVADLFVACLVMPLGAVYEISQG 291
            ::|||.::|:  .|..:||.  |...|::  .:....|...|.:.|:.:..:.:.|   :.|:..
Zfish    23 STVLLAVIII--SINGMFVF--IFFRRSIFHSDPRYILYIHLVMNDMLMVFISVVL---FVITFA 80

  Fly   292 WILGPELCDIWTSCDVLCCTASILH------LVAIAVDRYWAVTNIDYIHSRTSNR-VFMMIFCV 349
            |...|.     ..|.:|....|:.|      |..:||:||.||....:.|...:.| .:::|..:
Zfish    81 WHNVPV-----PFCVLLLLITSVSHRNTPLTLAGMAVERYIAVCKPLHHHQICTVRWTYVLISLI 140

  Fly   350 WTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCT 394
            |:..::..||..|                ::..:..:.:|.|.||
Zfish   141 WSVGILPGLADFF----------------LLLINGPFALFITICT 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	38/175 (22%)
		TM helix 1	228..254	CDD:320454	8/24 (33%)
		TM helix 2	261..287	CDD:320454	4/25 (16%)
		TM helix 3	299..329	CDD:320454	10/35 (29%)
		TM helix 4	340..362	CDD:320454	5/22 (23%)
		TM helix 5	383..412	CDD:320454	4/12 (33%)
		7tm_GPCRs	<743..816	CDD:355774
		TM helix 6	747..772	CDD:341315
		TM helix 7	784..809	CDD:341315
or90d1	XP_017212233.1	7tm_4	25..>147	CDD:304433	31/133 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100