DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and or137-5

DIOPT Version :9

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:XP_001923211.1 Gene:or137-5 / 100149850 ZFINID:ZDB-GENE-070806-26 Length:310 Species:Danio rerio


Alignment Length:247 Identity:53/247 - (21%)
Similarity:85/247 - (34%) Gaps:74/247 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 LNVTTSKV-AEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANY-LVASLAV 270
            :|.|..:| |:|.|...|......|:.|  |.:..|..:||. .........|...| |...|.:
Zfish     1 MNSTVLQVNAQDRFRDALVRNFIVVIFG--ITINSINGLFVF-TFFRSSVFYNDPRYILYIHLVI 62

  Fly   271 ADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTA------SILHLVAIAVDRYWAVT 329
            .|:.:..:.:.|..   ::..|...|     ...|.||...|      |:|.|..::|:||.|:.
Zfish    63 NDMLMVFVSVSLSV---MAYAWRNVP-----IPFCVVLLIIASKTHKNSVLTLAGMSVERYIAIC 119

  Fly   330 NIDYIHS-RTSNRVFMMIFCVWTAAVIVSLA---------PQFGWKDPDYLQRIEQQKCMVSQDV 384
            ...:.|. .|..|.:::|..:|:..|:..|:         |.|..||                  
Zfish   120 KPLHHHQICTVRRTYILISLIWSVGVLPGLSDFILLSVIDPTFYTKD------------------ 166

  Fly   385 SYQVFATCCT----FYVPL-----------------LVILALYWKIYQTARK 415
                  |.||    :..|.                 |:::..|.::..||||
Zfish   167 ------TICTASRLYNTPYHEELSKYMTGIYSSGVWLILIYTYCRVLITARK 212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 42/223 (19%)
TM helix 1 228..254 CDD:320454 6/25 (24%)
TM helix 2 261..287 CDD:320454 5/26 (19%)
TM helix 3 299..329 CDD:320454 11/35 (31%)
TM helix 4 340..362 CDD:320454 6/30 (20%)
TM helix 5 383..412 CDD:320454 6/49 (12%)
7tm_GPCRs <743..816 CDD:355774
TM helix 6 747..772 CDD:341315
TM helix 7 784..809 CDD:341315
or137-5XP_001923211.1 7tm_4 22..>147 CDD:304433 31/135 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24247
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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