Protein Alignment 5-HT1A and adra1ba

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_001922013.4
• Gene: adra1ba / 100149100
• ZFINID: ZDB-GENE-120510-1
• Length: 486
• Species: Danio rerio
• Alignment Length: 661
• Identity: 141/661 - (21%)
• Similarity: 221/661 - (33%)
• Gaps: 302/661 - (45%)

  Fly   183 NDSSLFGEMLANRSGQL-DLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVF 246
            :|:......|:|.|.:| |:.|.:...|.|    |...|: |.|.....::||..|:..|:||:.
Zfish     3 SDTDHAANFLSNASSELSDVSNSSSSGNGT----APSSFS-LSRALPLGMVLGAFIVFAIVGNIL 62

  Fly   247 VIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCT 311
            ||.:::..|:|:...||.:.:||:|||.::..|:|:.|..||...|:.|...||||.:.||||||
Zfish    63 VILSVVCNRHLRIPTNYFIINLAMADLLLSTTVLPVSATREILNYWVFGRIFCDIWAAVDVLCCT 127

  Fly   312 ASILHLVAIAVDRYWAVT-NIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQ 375
            |||:.|..|::|||..|. .:.|....|..|..:.:..||..|.::|:.|..|||:|   ...:.
Zfish   128 ASIMSLCVISIDRYIGVRYPLQYPSIVTEKRALLAMLGVWVLAFVISIGPLLGWKEP---PSEDD 189

  Fly   376 QKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAAT 440
            ..|:::::..|.:|::..:||:||.||||:|.::|..|::
Zfish   190 TVCLITEEPFYALFSSLGSFYIPLAVILAMYCRVYIVAKR------------------------- 229

  Fly   441 DTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKS 505
                                                                    ::.|::
Zfish   230 --------------------------------------------------------TTKNLE--- 235

  Fly   506 RAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREEL 570
             |||.......|::....|      .:|..|                           |||
Zfish   236 -AGVMKEHMDSNELTLRIH------YKGSQT---------------------------QED---- 262

  Fly   571 EDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGA 635
                                                                             
Zfish   263 ----------------------------------------------------------------- 262

  Fly   636 STSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRS 700
                                                       |.:.|
Zfish   263 -------------------------------------------CTKGH----------------- 267

  Fly   701 RQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWL 765
                                  ..||:.         .:.|:..||:||||||.::.|.|::|||
Zfish   268 ----------------------LRSSLT---------VKLLKFSREKKAAKTLGVVVGMFILCWL 301

  Fly   766 PFFVMALTMPLCA---ACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL------- 820
            |||   |.:|:.:   :.:..::...:..|||||||.|||:||..:|.||:|||.|||
Zfish   302 PFF---LALPIGSFNTSLRPPETFFKVIFWLGYFNSCLNPIIYPCYSREFKQAFIRILRCQCQQK 363

  Fly   821 -FGGHRPVHYR 830
             ..|.|..:||
Zfish   364 KQQGWRAYNYR 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	68/186 (37%)
		TM helix 1	228..254	CDD:320454	8/25 (32%)
		TM helix 2	261..287	CDD:320454	10/25 (40%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	12/28 (43%)
		7tm_GPCRs	<743..816	CDD:475119	34/75 (45%)
		TM helix 6	750..772	CDD:410628	12/21 (57%)
		TM helix 7	784..809	CDD:410628	12/24 (50%)
adra1ba	XP_001922013.4	None