DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and adrb2

DIOPT Version :10

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_001116897.2 Gene:adrb2 / 100144654 XenbaseID:XB-GENE-494302 Length:419 Species:Xenopus tropicalis


Alignment Length:614 Identity:117/614 - (19%)
Similarity:174/614 - (28%) Gaps:328/614 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly   226 MAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQ 290
            |....:::..::||.::|||.||.||...:.||.|.||.:.|||.|||.:..:|:|.||...|..
 Frog    37 MVGMGIIMSCIVLVIVLGNVLVITAIAKFQRLQTVTNYFITSLACADLLMGLIVVPFGASSIILD 101

  Fly   291 GWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAV 354
            .|:.....|:.|||.|:||.||||..|..||||||:|:|: ..|....|..:..::|..||..:.
 Frog   102 TWVFNNFWCEFWTSVDILCVTASIETLCVIAVDRYFAITSPFRYQSLLTKCKARIVILLVWVVST 166

  Fly   355 IVSLAPQF-GWKDPDYLQRIEQQK----------CMVSQDVSYQVFATCCTFYVPLLVILALYWK 408
            :.|..|.: .|      .|||::.          |....:.:|.:.::..:||:||:|::.:|.:
 Frog   167 LTSFLPIYMHW------YRIEEESALHCYDDPSCCFFFTNPAYAISSSIISFYLPLVVMIFVYAR 225

  Fly   409 IYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASG 473
            ::|.|:|                                                          
 Frog   226 VFQEAKK---------------------------------------------------------- 232

  Fly   474 GRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAK 538
                                                                             
 Frog   233 ----------------------------------------------------------------- 232

  Fly   539 SSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKAN 603
                                                                             
 Frog   233 ----------------------------------------------------------------- 232

  Fly   604 GVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGP 668
                              ||:|..||.|                                     
 Frog   233 ------------------QLKKIDKSEG------------------------------------- 242

  Fly   669 MTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQK 733
                                                    :.|.|.:||....:|          
 Frog   243 ----------------------------------------RFHNQNNQQDTNGKQ---------- 257

  Fly   734 VNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALT-------MPLCAACQISDSVASLFL 791
            .|||......| |.||.|||.||.|.|.:||||||::.:.       :|:        .|.:...
 Frog   258 GNKRTSKFWLK-EHKALKTLGIIMGTFTLCWLPFFIVNIVQVMHKDFIPV--------KVYNFLN 313

  Fly   792 WLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            |:||.||..||:|| ..||:||..|:.:|
 Frog   314 WVGYVNSAFNPLIY-CRSPDFRYTFQELL 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 66/197 (34%)
TM helix 1 228..254 CDD:320454 9/25 (36%)
TM helix 2 261..287 CDD:320454 12/25 (48%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 5/21 (24%)
TM helix 5 383..412 CDD:320454 7/28 (25%)
7tm_GPCRs <743..816 CDD:475119 32/79 (41%)
TM helix 6 750..772 CDD:410628 13/21 (62%)
TM helix 7 784..809 CDD:410628 10/24 (42%)
adrb2NP_001116897.2 7tmA_Beta2_AR 38..337 CDD:341355 114/607 (19%)
TM helix 1 39..65 CDD:341355 9/25 (36%)
TM helix 2 72..99 CDD:341355 12/26 (46%)
TM helix 3 110..140 CDD:341355 19/29 (66%)
TM helix 4 152..175 CDD:341355 5/22 (23%)
TM helix 5 200..232 CDD:341355 9/31 (29%)
TM helix 6 267..297 CDD:341355 17/30 (57%)
TM helix 7 306..331 CDD:341355 10/33 (30%)

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