Protein Alignment 5-HT1A and drd1c

DIOPT Version :10

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_004915948.1
• Gene: drd1c / 100124855
• XenbaseID: XB-GENE-5919679
• Length: 465
• Species: Xenopus tropicalis
• Alignment Length: 637
• Identity: 132/637 - (20%)
• Similarity: 203/637 - (31%)
• Gaps: 327/637 - (51%)

  Fly   209 NVTTSKVAED---DFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQN-VANYLVASLA 269
            |||.:.:..|   ..:.|...|:|.:||.|:||.|::||..|..|:|..|:|:: |.|:.|.|||
 Frog     8 NVTVNVLHADLDVGSSDLSLRALTGLLLSLLILSTLLGNTLVCLAVIKFRHLRSKVTNFFVISLA 72

  Fly   270 VADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDY 333
            |:|||||.||||..||.|::..|:.| :.||.|.:.|::|.|||||:|..|::|||||:.: ..|
 Frog    73 VSDLFVALLVMPWKAVTEVAGYWLFG-DFCDTWVAFDIMCSTASILNLCIISLDRYWAIASPFRY 136

  Fly   334 IHSRTSNRVFMMIFCVWTAAVIVSLAP-QFGWKDPDYLQRIEQ--------QKCMVSQDVSYQVF 389
            ....|....|:||...||.::::|..| |..|...   |.:::        :.|..|.:.:|.:.
 Frog   137 ERKMTQRVAFIMIGVAWTLSILISFIPVQLSWHKS---QEVDEELNAINHTENCDSSLNRTYAIS 198

  Fly   390 ATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRF 454
            ::..:||:|:::::..|.:||:.|
 Frog   199 SSLISFYIPVVIMIGTYTRIYRIA----------------------------------------- 222

  Fly   455 STAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQI 519
                                                                             
 Frog   223 ----------------------------------------------------------------- 222

  Fly   520 ATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTA 584
                                                                             
 Frog   223 ----------------------------------------------------------------- 222

  Fly   585 TSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISAL 649
                                         |.|:.::..|:::|:....|
 Frog   223 -----------------------------QTQIRRISSLERAVEHAQSG---------------- 242

  Fly   650 SPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQA 714
                                             ||.|...|.
 Frog   243 ---------------------------------HPDCSNENS----------------------- 251

  Fly   715 HQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLC-- 777
                             .|.:.||||       |..|||:||.|.||.|||||||:...:|.|
 Frog   252 -----------------LKTSFRKET-------KVLKTLSIIMGVFVFCWLPFFVLNCMIPFCHM 292

  Fly   778 ---------AACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
                     ..| :|::..::|:|.|:.||:||||||. |:.:||:||..||
 Frog   293 SLPGQNEPEPPC-VSETTFNIFVWFGWANSSLNPVIYA-FNADFRKAFTTIL 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	74/196 (38%)
		TM helix 1	228..254	CDD:320454	12/25 (48%)
		TM helix 2	261..287	CDD:320454	17/25 (68%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	7/22 (32%)
		TM helix 5	383..412	CDD:320454	7/28 (25%)
		7tm_GPCRs	<743..816	CDD:475119	34/83 (41%)
		TM helix 6	750..772	CDD:410628	15/21 (71%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)
drd1c	XP_004915948.1	7tmA_D1-like_dopamine_R	46..338	CDD:320185	114/593 (19%)
		TM helix 2	64..91	CDD:320185	17/26 (65%)
		TM helix 3	101..131	CDD:320185	17/29 (59%)
		TM helix 4	143..163	CDD:320185	6/19 (32%)
		TM helix 5	192..222	CDD:320185	7/29 (24%)
		TM helix 6	257..287	CDD:320185	20/36 (56%)
		TM helix 7	307..332	CDD:320185	12/25 (48%)