DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1A and htr1fb

DIOPT Version :9

Sequence 1:NP_001356890.1 Gene:5-HT1A / 37196 FlyBaseID:FBgn0004168 Length:846 Species:Drosophila melanogaster
Sequence 2:XP_005159986.1 Gene:htr1fb / 100004819 ZFINID:ZDB-GENE-090312-140 Length:372 Species:Danio rerio


Alignment Length:617 Identity:152/617 - (24%)
Similarity:220/617 - (35%) Gaps:277/617 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 DFTQLL--RMAVTSVLLGL----MILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVAC 277
            |.:.:|  :|:.:.:||.|    :.:.|...|..||.||::.|.|...||||:.||||.||.||.
Zfish    10 DLSDVLASKMSPSKILLSLTLSFLAVATTAINSLVITAILITRKLHQPANYLICSLAVTDLLVAV 74

  Fly   278 LVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNR 341
            ||||:..||...:.|:|||.:|.:|...||.|||.|||||.|||:|||.|:|: :.|...||..|
Zfish    75 LVMPVSIVYIAEETWVLGPIVCHLWLGVDVTCCTCSILHLAAIALDRYRAITDAVAYSQKRTYKR 139

  Fly   342 VFMMIFCVWTAAVIVSLA-------PQFGWKDPDYLQRIEQQKCMVSQD-VSYQVFATCCTFYVP 398
            |.:.|..:||.:::|||.       |:..:||    .:.|...|::..| |::.|::|...||:|
Zfish   140 VIVTILSLWTLSILVSLPPLVWRKFPKVEFKD----GKREPMDCLIEHDHVAFTVYSTFGAFYIP 200

  Fly   399 LLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGS 463
            |.:||.||:|||:.|....:||                                           
Zfish   201 LALILVLYYKIYKAAEMLRNRR------------------------------------------- 222

  Fly   464 AVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVAL 528
                              |:|.....||                                     
Zfish   223 ------------------GSSRLVKQTV------------------------------------- 232

  Fly   529 AKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGT 593
                      ||..:.||:                       .|:|..:.|              
Zfish   233 ----------SSVMLPGMS-----------------------SDKDIALSP-------------- 250

  Fly   594 NESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQG 658
               :..|                     .::||.                               
Zfish   251 ---DSFC---------------------PIEKSF------------------------------- 260

  Fly   659 VGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQ 723
                                            ..|||...|.|                      
Zfish   261 --------------------------------SDPSTDGERVR---------------------- 271

  Fly   724 LSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVAS 788
            ::|.:..:.:|.:.    ...|||:||.||.:|.|||||||||||:..:.:.:|..|..|..:|.
Zfish   272 ITSSSGNLIRVRRN----PGARERRAALTLGLILGAFVVCWLPFFLKEVIVNICPTCTTSAVLAD 332

  Fly   789 LFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ...||||.||.:||:|||||:.:|::|||::|
Zfish   333 FLTWLGYLNSLINPLIYTIFNEDFKKAFKKLL 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1ANP_001356890.1 7tmA_5-HT1A_invertebrates 227..>413 CDD:320454 84/198 (42%)
TM helix 1 228..254 CDD:320454 9/29 (31%)
TM helix 2 261..287 CDD:320454 17/25 (68%)
TM helix 3 299..329 CDD:320454 19/29 (66%)
TM helix 4 340..362 CDD:320454 9/28 (32%)
TM helix 5 383..412 CDD:320454 15/29 (52%)
7tm_GPCRs <743..816 CDD:355774 37/72 (51%)
TM helix 6 747..772 CDD:341315 17/24 (71%)
TM helix 7 784..809 CDD:341315 13/24 (54%)
htr1fbXP_005159986.1 7tm_1 41..349 CDD:278431 135/569 (24%)
7tm_4 41..>165 CDD:304433 60/123 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D310620at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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