Protein Alignment 5-HT1A and htr1aa

DIOPT Version :9

• Sequence 1: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001116793.1
• Gene: htr1aa / 100001828
• ZFINID: ZDB-GENE-071203-1
• Length: 398
• Species: Danio rerio
• Alignment Length: 618
• Identity: 173/618 - (27%)
• Similarity: 244/618 - (39%)
• Gaps: 238/618 - (38%)

  Fly   209 NVTTSKVAEDDFTQLLRMAVT-----SVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASL 268
            |.|.|:....:.|.:..:|::     |:.|..:||..|:||..|||||.|||:||||||||:.||
Zfish     6 NTTESQDWSGNATSVSEVALSYQIIGSLFLAALILFAILGNACVIAAIALERSLQNVANYLIGSL 70

  Fly   269 AVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-ID 332
            ||.||.|:.||:|:.|:|::...|.||.|:|||:.|.||||||:|||||.|||:|||||:|: ||
Zfish    71 AVTDLMVSVLVLPMAALYQVLNKWTLGQEMCDIFISLDVLCCTSSILHLCAIALDRYWAITDPID 135

  Fly   333 YIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYV 397
            |::.||..|..::|...|.....:|:.|..||:.|:  .|.:...|.:|||..|.:::|...||:
Zfish   136 YVNKRTPRRAAILISLTWLIGFSISIPPMLGWRKPE--DRADPDACTISQDHGYTIYSTFGAFYI 198

  Fly   398 PLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTG 462
            ||:::|.||.:|::.||.||.:
Zfish   199 PLILMLVLYGRIFRAARFRIRK------------------------------------------- 220

  Fly   463 SAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVA 527
                                       ||:.||
Zfish   221 ---------------------------TVKKTE-------------------------------- 226

  Fly   528 LAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAG 592
            .||...|..|.|.|    :.|         |..:||             ||..
Zfish   227 KAKIADKCLAVSPA----LFP---------RKANGE-------------VGKT------------ 253

  Fly   593 TNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQ 657
            ...|.:.| |||.....|.....::.:||.:.|:..|
Zfish   254 WRRSVEPC-ANGALKNSDDGESFEITEVQSISKNHLS---------------------------- 289

  Fly   658 GVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQ 722
                                              .|:.|:|
Zfish   290 ----------------------------------LPNNPQP------------------------ 296

  Fly   723 QLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVA 787
               ...|..:|..:.|..:...||||..|||.||.|.|:.||||||::||.:|.|..|.:.:.:.
Zfish   297 ---CFENRNEKNTEAKRKVALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCQDCFMPEWLG 358

  Fly   788 SLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820
            ::..||||.||.||||||..|:.:|:.|||:||
Zfish   359 AVINWLGYSNSLLNPVIYAYFNKDFQNAFKKIL 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	92/191 (48%)
		TM helix 1	228..254	CDD:320454	12/30 (40%)
		TM helix 2	261..287	CDD:320454	15/25 (60%)
		TM helix 3	299..329	CDD:320454	23/29 (79%)
		TM helix 4	340..362	CDD:320454	5/21 (24%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:355774	36/72 (50%)
		TM helix 6	747..772	CDD:341315	15/24 (63%)
		TM helix 7	784..809	CDD:341315	12/24 (50%)
htr1aa	NP_001116793.1	7tm_4	39..>161	CDD:304433	69/121 (57%)
		7tm_1	45..376	CDD:278431	154/562 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595732
Domainoid	1	1.000	279	1.000	Domainoid score	I1659
eggNOG	1	0.900	-	-		E33208_3BCYC
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20148
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2621
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310620at33208
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X366
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.800