DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT1A and or90a1

DIOPT Version :9

Sequence 1:	NP_001356890.1	Gene:	5-HT1A / 37196	FlyBaseID:	FBgn0004168	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001082920.1	Gene:	or90a1 / 100001167	ZFINID:	ZDB-GENE-070806-22	Length:	315	Species:	Danio rerio

Alignment Length:	305	Identity:	63/305 - (20%)
Similarity:	111/305 - (36%)	Gaps:	73/305 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 INGTGG----LNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFV--IAAIILERNLQNV 260
            :|.|.|    |..|.:.....:|..:|...:.|.:.|.::.......:|.  ...|:....:.|.
Zfish     1 MNSTAGQQLLLRDTFAMAFMKNFIVVLVWFLLSYINGSVVATFFRHQIFYEDPRYILFIHMVIND 65

  Fly   261 ANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRY 325
            |..|..::|   ||:...::     |.||.|      :|..:....|....::.::|..:|::||
Zfish    66 AVQLTVTIA---LFLVSYIL-----YTISVG------VCCFFILVAVFTTRSTPVNLAGMAIERY 116

  Fly   326 WAVT-NIDYIHSRTSNRVFMMIFCVWTAAVI-------VSLAP--------------QFGWKDPD 368
            .|:. .:.:....|.:|.:::|..:|..:|:       |:||.              |..:|||.
Zfish   117 IAICYPLRHAQICTVHRAYVLIGVIWFVSVVPDITDLFVTLATEPLSFFQTSVFCLRQNVFKDPV 181

  Fly   369 YLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQ 433
            .|.:.:      :.|..|        |.:..|.:|..|.||..||...             :...
Zfish   182 LLYKRQ------AFDGIY--------FSLVFLTLLCTYLKIMFTAHSH-------------STEN 219

  Fly   434 PDGGAATDT-KLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRAL 477
            .....||:| .||.|:|.:...|.........:.:..|   ||.|
Zfish   220 TSAKRATNTILLHGLQLIMCLLSYISPSVEGILNIIFP---GRVL 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	42/209 (20%)
		TM helix 1	228..254	CDD:320454	4/27 (15%)
		TM helix 2	261..287	CDD:320454	5/25 (20%)
		TM helix 3	299..329	CDD:320454	7/29 (24%)
		TM helix 4	340..362	CDD:320454	7/42 (17%)
		TM helix 5	383..412	CDD:320454	8/28 (29%)
		7tm_GPCRs	<743..816	CDD:355774
		TM helix 6	747..772	CDD:341315
		TM helix 7	784..809	CDD:341315
or90a1	NP_001082920.1	7tm_4	<108..298	CDD:304433	40/184 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100