DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15116 and GPX4

DIOPT Version :9

Sequence 1:	NP_611393.2	Gene:	CG15116 / 37194	FlyBaseID:	FBgn0034415	Length:	193	Species:	Drosophila melanogaster
Sequence 2:	NP_001034937.1	Gene:	GPX4 / 2879	HGNCID:	4556	Length:	234	Species:	Homo sapiens

Alignment Length:	163	Identity:	62/163 - (38%)
Similarity:	90/163 - (55%)	Gaps:	11/163 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DMRWRLTIHALTVRDTFGNPVQLDTFAGHVLLIVNIASKCGLTLSQYNGLRYLLEEYEDQGLRIL 97
            |.|...::|..:.:|..|:.|.||.:.|.|.::.|:||: |.|...|..|..|...|.:.|||||
Human    71 DWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRIL 135

  Fly    98 NFPCNQFGGQMPESDGQEMLDHLRREGANIG-HLFAKIDVKGAQADPLYKLLTRHQ-------HD 154
            .|||||||.|.|.|: :|:.:.  ..|.|:. .:|:||.|.|..|.||:|.:....       :.
Human   136 AFPCNQFGKQEPGSN-EEIKEF--AAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNA 197

  Fly   155 IEWNFVKFLVDRKGNIHKRYGAELEPVALTDDI 187
            |:|||.|||:|:.|.:.||||...||:.:..|:
Human   198 IKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDL 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15116	NP_611393.2	GSH_Peroxidase	39..187	CDD:238207	59/155 (38%)
GPX4	NP_001034937.1	GSH_Peroxidase	77..230	CDD:238207	59/155 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7330
eggNOG	1	0.900	-	-		E1_COG0386
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48732
OrthoDB	1	1.010	-	-		D1483113at2759
OrthoFinder	1	1.000	-	-		FOG0000791
OrthoInspector	1	1.000	-	-		otm41216
orthoMCL	1	0.900	-	-		OOG6_100297
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X276
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.730