Protein Alignment 5-HT1B and TAAR2

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001028252.1
• Gene: TAAR2 / 9287
• HGNCID: 4514
• Length: 351
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 104/566 - (18%)
• Similarity: 156/566 - (27%)
• Gaps: 302/566 - (53%)

  Fly    76 EQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVA 140
            |.||:      |...:||...:...|.:||.||:.:|.:|...:.|....|:|:.|:|:.|..:.
Human    35 ENERS------LGVRVAMYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLG 93

  Fly   141 CLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTV-------TNIDYN 198
            ..:||...:..:.|.|..|...|.|:.|.|::....||.||.::|.||::.:       |.|...
Human    94 FTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIP 158

  Fly   199 NLRTPRRVFLMIFCVW-----FA-ALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCC 257
            .::.     |::.| |     || .::.|.|         |...||          ||.|...|.
Human   159 VIKR-----LLLLC-WSVPGAFAFGVVFSEA---------YADGIE----------GYDILVACS 198

  Fly   258 T------------------FYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRE 304
            :                  |:.|..:::.:|.||:.::||
Human   199 SSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRK------------------------- 238

  Fly   305 LKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSM 369
                                                                             
Human   239 ----------------------------------------------------------------- 238

  Fly   370 AAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQH 434
                                                                             
Human   239 ----------------------------------------------------------------- 238

  Fly   435 HLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNA 499
                 |.:||..|
Human   239 -----HAHAINNL---------------------------------------------------- 246

  Fly   500 GVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLP-FFVMALTMSLCKEC 563
                               :..|..:.|:::|||:||.|:.|.|::||.| ||.:.|...|
Human   247 -------------------RENQNNQVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFL---- 288

  Fly   564 EIHTAVASLF---LWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGR 606
            ...|.|. ||   .|.||||||.||:||..|.|.||||.|.||.|:
Human   289 NFSTPVV-LFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGK 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/25 (36%)
		TM helix 2	125..151	CDD:320454	7/25 (28%)
		TM helix 3	163..193	CDD:320454	11/36 (31%)
		TM helix 4	204..226	CDD:320454	7/27 (26%)
		TM helix 5	247..276	CDD:320454	9/46 (20%)
		7tm_GPCRs	<525..599	CDD:475119	36/77 (47%)
		TM helix 6	533..555	CDD:410628	11/22 (50%)
		TM helix 7	567..592	CDD:410628	15/27 (56%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	54/226 (24%)
TAAR2	NP_001028252.1	7tmA_TAAR2_3_4	44..326	CDD:320437	95/542 (18%)
		TM helix 1	45..71	CDD:320437	9/25 (36%)
		TM helix 2	78..104	CDD:320437	7/25 (28%)
		TM helix 3	116..146	CDD:320437	11/29 (38%)
		TM helix 4	158..181	CDD:320437	5/28 (18%)
		TM helix 5	206..235	CDD:320437	5/28 (18%)
		TM helix 6	255..285	CDD:320437	14/29 (48%)
		TM helix 7	294..319	CDD:320437	14/25 (56%)