DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and htr2b

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001038208.1 Gene:htr2b / 751784 ZFINID:ZDB-GENE-081022-57 Length:443 Species:Danio rerio


Alignment Length:555 Identity:125/555 - (22%)
Similarity:207/555 - (37%) Gaps:200/555 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 AVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG-WI 157
            |:::.|:|:.||.||:.||.|:.|||.|||..|:.:.|||||||.|..||||:..|..:.|. |.
Zfish    18 ALLILLVIVPTIGGNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTVLYNSTWP 82

  Fly   158 LGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVS 221
            |...||.||...|||..||||:||.||:.|||..:.. |.::..::..:|...|..||..::.::
Zfish    83 LADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIALVWLISIGIA 147

  Fly   222 L-APQFGWKDPDYMK-RIEEQH-CMVSQD--VGYQIFATCCTFYVPLLVILFLYWKIYIIARKRI 281
            : .|..|.:..|:.. ...:.| |::|.:  ..::::.:...|::||.:::.:|.....:.||:.
Zfish   148 IPIPIKGLQFFDHPNITFNKNHTCLLSPEGFRDFKVYGSLVAFFIPLAIMMIIYLLTIQVLRKKA 212

  Fly   282 ----QRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRK 342
                .|.|:.|.:....:        ||                                     
Zfish   213 YLLRSRAARPSISTVFQQ--------EL------------------------------------- 232

  Fly   343 RMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVS 407
                         :|:|..|..|           .|..|.|:.|                     
Zfish   233 -------------SVLASPEKMV-----------ISNGIKRDRT--------------------- 252

  Fly   408 SDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGA 472
                                             ||.:.|:               |..|..|...
Zfish   253 ---------------------------------LNPVNPI---------------TGDEVPLRRM 269

  Fly   473 GTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLA 537
            .|:.                                           :|.:.....|::|::.|.
Zfish   270 STIG-------------------------------------------KRSMQNLTNEQRASKVLG 291

  Fly   538 IITGAFVICWLPFFVMALTMSLCKEC--EIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFK 600
            |:...||:.|.|||:..:|..||:.|  .:...:..:|.|:||.:|.:||::||:||..||.||:
Zfish   292 IVFMLFVVMWCPFFITNVTSVLCERCNGNLVDQLLDIFQWVGYVSSGINPLVYTLFNRTFRLAFR 356

  Fly   601 RILFGRKAAARA----RSAKIXFQ--LKDNEDQYL 629
            |.:.....:.|.    |.:||.|:  :.:|..:::
Zfish   357 RYITCNYKSVRTPKLQRRSKISFRSSVTENSKRFM 391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 10/23 (43%)
TM helix 2 125..151 CDD:320454 14/25 (56%)
TM helix 3 163..193 CDD:320454 17/29 (59%)
TM helix 4 204..226 CDD:320454 5/22 (23%)
TM helix 5 247..276 CDD:320454 4/30 (13%)
7tm_GPCRs <525..599 CDD:475119 27/75 (36%)
TM helix 6 533..555 CDD:410628 8/21 (38%)
TM helix 7 567..592 CDD:410628 9/24 (38%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 70/203 (34%)
htr2bNP_001038208.1 7tm_GPCRs 15..362 CDD:475119 119/524 (23%)
TM helix 1 17..41 CDD:410628 10/22 (45%)
TM helix 2 50..72 CDD:410628 13/21 (62%)
TM helix 3 89..111 CDD:410628 13/21 (62%)
TM helix 4 134..150 CDD:410628 3/15 (20%)
TM helix 5 179..202 CDD:410628 3/22 (14%)
TM helix 6 287..309 CDD:410628 8/21 (38%)
TM helix 7 323..348 CDD:410628 9/24 (38%)

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