Protein Alignment 5-HT1B and adrb2a

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001096122.1
• Gene: adrb2a / 565838
• ZFINID: ZDB-GENE-100414-3
• Length: 405
• Species: Danio rerio
• Alignment Length: 543
• Identity: 123/543 - (22%)
• Similarity: 189/543 - (34%)
• Gaps: 228/543 - (41%)

  Fly    71 DLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVA 135
            ||:......|:.:..|  :|..:..::.:::|:.:.|||.||.||...:.||||.|..:.|||.|
Zfish    11 DLICPNNTNASTKSEL--QMTVLGTLMSILVLIIVFGNVMVITAISRFQRLQNVTNCFITSLACA 73

  Fly   136 DLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNN 199
            ||.:..:|:|.||:|.|.|.|..|..|||.||:.||||.||||..|..||.|||..:|: ..|.:
Zfish    74 DLVMGLVVIPFGALYIILNTWHFGHFLCDFWTATDVLCVTASIETLCVIAMDRYIAITSPFRYQS 138

  Fly   200 LRTPRRVFLMIFCVWFAALIVSLAP-QFGWKDPDYMKRIEEQHCMVSQ------DV--GYQIFAT 255
            |.|..|...::..||..|.:||..| ...|    ::....|..|..:.      |:  .|.|.::
Zfish   139 LLTKNRARFIVLMVWVIAGLVSYLPIHMEW----WISTDNETLCCYNNTYCCEFDITYSYAIVSS 199

  Fly   256 CCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLE 320
            ..:||:||::::|:|.:::..|||                        :|||
Zfish   200 IISFYIPLVIMVFVYSRVFQEARK------------------------QLKK------------- 227

  Fly   321 AGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREE 385
                                                                        |.:.|
Zfish   228 ------------------------------------------------------------INKTE 232

  Fly   386 TEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQS 450
            ..|         ||             .::::.|:
Zfish   233 GRF---------HA-------------QKSNSRNQ------------------------------ 245

  Fly   451 IAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQ 515
                                                                      .:||.|.
Zfish   246 ----------------------------------------------------------DVANNHS 252

  Fly   516 KLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFN 580
            ::...::.....:|.||.:||.||.|.|.:|||||||    :::..:..:......:..|:||.|
Zfish   253 EMRSTKKAKFYLKEHKALKTLGIIMGVFTLCWLPFFV----LNVIPKGSVDIWTFRILNWIGYAN 313

  Fly   581 STLNPVIYTIFNPEFRRAFKRIL 603
            |..||:|| ..:|:||.|||.||
Zfish   314 SAFNPLIY-CGSPDFRYAFKEIL 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	8/25 (32%)
		TM helix 2	125..151	CDD:320454	11/25 (44%)
		TM helix 3	163..193	CDD:320454	18/29 (62%)
		TM helix 4	204..226	CDD:320454	7/22 (32%)
		TM helix 5	247..276	CDD:320454	9/30 (30%)
		7tm_GPCRs	<525..599	CDD:475119	28/73 (38%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	9/24 (38%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	73/205 (36%)
adrb2a	NP_001096122.1	7tm_GPCRs	31..331	CDD:475119	113/515 (22%)
		TM helix 1	31..55	CDD:410628	8/23 (35%)
		TM helix 2	64..86	CDD:410628	9/21 (43%)
		TM helix 3	102..124	CDD:410628	13/21 (62%)
		TM helix 4	147..163	CDD:410628	5/15 (33%)
		TM helix 5	192..215	CDD:410628	7/22 (32%)
		TM helix 6	270..291	CDD:410628	13/24 (54%)
		TM helix 7	300..325	CDD:410628	9/25 (36%)