Protein Alignment 5-HT1B and adra1ab

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_021334987.2
• Gene: adra1ab / 557259
• ZFINID: ZDB-GENE-060503-384
• Length: 431
• Species: Danio rerio
• Alignment Length: 521
• Identity: 134/521 - (25%)
• Similarity: 203/521 - (38%)
• Gaps: 198/521 - (38%)

  Fly    87 LVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYE 151
            :.|.:.:.:||.|.::..::||:.||.::...|||::|.:|.:.:||:|||.::.:|:|..||.|
Zfish    33 VTKTLVLGLVLVLFLIFGVMGNILVILSVACHRNLRSVTHYFIGNLAIADLLLSSVVLPFSAVSE 97

  Fly   152 ISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVWF 215
            ....|:.|..||:.||:.||||||||||.|..|:.||...|: .:.|.:..|.||....:..:|.
Zfish    98 ALGRWVFGRHLCNAWTALDVLCCTASILSLCVISVDRCMAVSYPLQYPSFATGRRAMTAVAALWA 162

  Fly   216 AALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKR 280
            .:..:|:.|.|||::|  |.. :|..|.|::|.||.||:..|:|||||.|||.:|.::|::||.:
Zfish   163 LSAAISVGPLFGWREP--MPE-DESVCRVNEDPGYAIFSAACSFYVPLAVILAMYCRVYVVARHK 224

  Fly   281 IQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMR 345
                                 .|.:.|.|.                     |.|..::....|:.
Zfish   225 ---------------------TRAMSKSRE---------------------TNGLSEQGMTLRIH 247

  Fly   346 ICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDA 410
            ....:|.                             ||:|
Zfish   248 CRKAQND-----------------------------TRKE------------------------- 258

  Fly   411 DDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTV 475
            |..|..|                     ||...:
Zfish   259 DAMRLKN---------------------SHFAFM------------------------------- 271

  Fly   476 AGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIIT 540
                                                          :||:..||:|||:||.|:.
Zfish   272 ----------------------------------------------RLLKFSREKKAAKTLGIVV 290

  Fly   541 GAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFG 605
            |.||:||||||::....|:........||..:..|||||||.|||:||..|:.||::||:.:|.|
Zfish   291 GCFVLCWLPFFLVLPISSIFPSHRPPDAVFKITFWLGYFNSCLNPIIYPCFSQEFKKAFQNVLHG 355

  Fly   606 R 606
            |
Zfish   356 R 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	7/25 (28%)
		TM helix 2	125..151	CDD:320454	10/25 (40%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	5/21 (24%)
		TM helix 5	247..276	CDD:320454	16/28 (57%)
		7tm_GPCRs	<525..599	CDD:475119	35/73 (48%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	76/196 (39%)
adra1ab	XP_021334987.2	None