Protein Alignment 5-HT1B and drd4-rs

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001012638.3
• Gene: drd4-rs / 503566
• ZFINID: ZDB-GENE-051113-172
• Length: 418
• Species: Danio rerio
• Alignment Length: 515
• Identity: 148/515 - (28%)
• Similarity: 217/515 - (42%)
• Gaps: 124/515 - (24%)

  Fly    93 MAVVLGL-MILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG- 155
            :|::.|: :||:.|:|||.|..:::.||:|:...||.:.|||||||.:|.||:||....|...|
Zfish    20 LALICGVPLILIIILGNVLVCLSVLTERSLKTATNYFIVSLAVADLLLAILVLPLYVYSEFLGGI 84

  Fly   156 WILGPELCDIWTSCDVLCCTASILHLVAIAADRY-WTVTNIDYNNLRTPRRVFLMIFCVWFAALI 219
            |.|...:||...:.||:.||||||:|.||:.||| ..|..:.||..:...|...:|...|..:|.
Zfish    85 WTLSMYICDALMTMDVMLCTASILNLCAISVDRYIAVVVPLKYNRNQFSVRQLALITATWVLSLG 149

  Fly   220 VSLAPQFGWKD-PDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQR 283
            |:....||... |:     ...|....:|..:.::::.|:|:||..|:||||:.::
Zfish   150 VASPVIFGLNQVPN-----RNPHVCKLEDNQFVVYSSVCSFFVPCPVMLFLYYWMF--------- 200

  Fly   284 RAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICF 348
                               |.||:..|.|.....|     |.|            |.|:.:.:..
Zfish   201 -------------------RGLKRWSSGRNRSHLR-----RPP------------RGRRSLSLRL 229

  Fly   349 GRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDY 413
            |       .....|...||......:. |.|:.|              |...|..|.:||.:.
Zfish   230 G-------AALQKEKGRAREKVVYLMP-AGLSPT--------------SLTATPTTPISSTSP-- 270

  Fly   414 RTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGA 478
                    :||       |...|....:    |.|:|..|         |....::|.|.....|
Zfish   271 --------VTL-------TTDDLAEGQM----PGAESDPM---------TTQMDSVSDAENPERA 307

  Fly   479 VAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAF 543
            ....||..:|      .|||            ..||......:....:.|||||.:.|.::.|.|
Zfish   308 TEDDSGRENG------VGKN------------HRPHTGRRHSKSNRVSGRERKAMKVLPVVVGVF 354

  Fly   544 VICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            :.||.||||:.:|.:||:.|:|...:.|:..||||.||.:||:|||.||.|||..|.::|
Zfish   355 LACWTPFFVVHVTKALCESCDIGPTLISVVTWLGYVNSAVNPIIYTAFNVEFRNVFHKLL 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/25 (36%)
		TM helix 2	125..151	CDD:320454	14/25 (56%)
		TM helix 3	163..193	CDD:320454	16/30 (53%)
		TM helix 4	204..226	CDD:320454	5/21 (24%)
		TM helix 5	247..276	CDD:320454	10/28 (36%)
		7tm_GPCRs	<525..599	CDD:475119	36/73 (49%)
		TM helix 6	533..555	CDD:410628	9/21 (43%)
		TM helix 7	567..592	CDD:410628	12/24 (50%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	68/197 (35%)
drd4-rs	NP_001012638.3	7tmA_D4_dopamine_R	19..410	CDD:320434	146/509 (29%)
		TM helix 1	20..46	CDD:320434	9/25 (36%)
		TM helix 2	53..79	CDD:320434	14/25 (56%)
		TM helix 3	92..122	CDD:320434	16/29 (55%)
		TM helix 4	134..157	CDD:320434	5/22 (23%)
		TM helix 5	173..202	CDD:320434	10/56 (18%)
		TM helix 6	338..368	CDD:320434	14/29 (48%)
		TM helix 7	378..403	CDD:320434	12/24 (50%)