Protein Alignment 5-HT1B and drd4b

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001012636.1
• Gene: drd4b / 503565
• ZFINID: ZDB-GENE-070508-3
• Length: 382
• Species: Danio rerio
• Alignment Length: 517
• Identity: 131/517 - (25%)
• Similarity: 206/517 - (39%)
• Gaps: 172/517 - (33%)

  Fly    94 AVVLGLMILVTII-GNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG-W 156
            |:|.|:::::.|| |||.|..::..|:.|:...||.:.|||||||.:|.||:||....|...| |
Zfish    20 ALVFGILLIIVIICGNVLVCLSVYKEKALKTTTNYFIVSLAVADLMLAVLVLPLFVYAEFQGGVW 84

  Fly   157 ILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVWFAALIV 220
            .|...:||...:.||:.|||||.:|.||:.||:..|: .::||......|..:::...|..||.|
Zfish    85 SLNVSVCDGLMTMDVMLCTASIFNLCAISVDRFIAVSIPLNYNRKHVDYRQIILLSATWLLALAV 149

  Fly   221 SLAPQFG-----WKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKR 280
            :....||     .:||...|         .:|..|.::::.|:|::|..::|.||:.::
Zfish   150 ASPVIFGINNVPQRDPSECK---------LEDNNYVVYSSVCSFFIPCPIMLMLYFGMF------ 199

  Fly   281 IQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMR 345
                                  ..|:|....|:|                        :.|..::
Zfish   200 ----------------------HGLRKWEETRKA------------------------KLRNSIQ 218

  Fly   346 ICFGRNTNTANVVAGSE--GAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSS 408
            .|  |:...|.|.|...  ||:..|:..:.           |.:.:.|:.:
Zfish   219 AC--RSLQHAAVAAALPPLGALPASLPRVI-----------ERDLAQSSLE-------------- 256

  Fly   409 DADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAG 473
            :.||:                  ||         .:.|.                |.|...|...
Zfish   257 ELDDF------------------TQ---------PVCPF----------------PPEYKNSTIQ 278

  Fly   474 TVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAI 538
            |||                     .:.:..|          ||..::::.....|||||.:.|.:
Zfish   279 TVA---------------------YSDIQYG----------QKTQRKKRAKINGRERKAMRVLPV 312

  Fly   539 ITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFK 600
            :.|.|:.||.||||:..|.:||:.|.|.:.:.|...||||.||.|||:|||:||.|||:.|:
Zfish   313 VVGVFLFCWTPFFVVHTTRALCESCHISSDLMSTVTWLGYVNSALNPIIYTVFNTEFRKFFR 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/24 (38%)
		TM helix 2	125..151	CDD:320454	14/25 (56%)
		TM helix 3	163..193	CDD:320454	14/29 (48%)
		TM helix 4	204..226	CDD:320454	5/21 (24%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	37/73 (51%)
		TM helix 6	533..555	CDD:410628	9/21 (43%)
		TM helix 7	567..592	CDD:410628	13/24 (54%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	64/200 (32%)
drd4b	NP_001012636.1	7tmA_D4_dopamine_R	20..373	CDD:320434	130/514 (25%)
		TM helix 1	20..45	CDD:320434	9/24 (38%)
		TM helix 2	52..78	CDD:320434	14/25 (56%)
		TM helix 3	91..121	CDD:320434	14/29 (48%)
		TM helix 4	133..156	CDD:320434	5/22 (23%)
		TM helix 5	172..201	CDD:320434	8/56 (14%)
		TM helix 6	301..331	CDD:320434	14/29 (48%)
		TM helix 7	341..366	CDD:320434	13/24 (54%)