Protein Alignment 5-HT1B and adra1bb

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001007359.1
• Gene: adra1bb / 492486
• ZFINID: ZDB-GENE-041114-51
• Length: 481
• Species: Danio rerio
• Alignment Length: 554
• Identity: 133/554 - (24%)
• Similarity: 211/554 - (38%)
• Gaps: 218/554 - (39%)

  Fly    61 INGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVA 125
            :||.|                :|..||.:.:.:.:|||..|...|.||:.||.:::..|:|::..
Zfish    34 LNGTG----------------LEPLLLSRAVPLGLVLGFFITFAIAGNILVILSVVCNRHLRSPT 82

  Fly   126 NYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYW 190
            ||.:.:||:|||.:...|:|:.|..|:...|:.|...||:|.:.|||||||||:.|..|:.|||.
Zfish    83 NYFIVNLAIADLLLGTTVLPVSATLEVVGHWVFGRIFCDVWAAVDVLCCTASIMSLCVISIDRYI 147

  Fly   191 TVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFA 254
            .|:: :.|.|:.|.||..|.:..||..:|::|:.|..|||:|   ...::..|.::::..|.:|:
Zfish   148 GVSHPLQYPNIVTGRRALLAMLGVWVLSLVISIGPLLGWKEP---PSPDDTVCAINEEPFYALFS 209

  Fly   255 TCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRL 319
            :..:||:||:|||.:|.::|::|::                                   ..|.|
Zfish   210 SLGSFYIPLIVILVMYCRVYVVAKR-----------------------------------TTKNL 239

  Fly   320 EAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITRE 384
            |||.:|                        .:.|:..:..
Zfish   240 EAGVKT------------------------ESMNSGEITL------------------------- 255

  Fly   385 ETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQ 449
                       :.|.|::   |..||...|...|...:|:
Zfish   256 -----------RIHRGSQ---VHEDAGKSRAHQARNSLTV------------------------- 281

  Fly   450 SIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPH 514
                                                                             
Zfish   282 ----------------------------------------------------------------- 281

  Fly   515 QKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYF 579
                   :||:..||:|||:||.::.|.|.:||||||:....:|..........|:|:..|||||
Zfish   282 -------KLLKFSREKKAAKTLGVVVGMFTLCWLPFFLTLPIVSFNTSLRPPETVSSIIFWLGYF 339

  Fly   580 NSTLNPVIYTIFNPEFRRAFKRILFGRKAAARAR 613
            ||.|||:||..::.||:.||.|||   |...|.|
Zfish   340 NSCLNPIIYPCYSREFKLAFIRIL---KCRCRRR 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/25 (36%)
		TM helix 2	125..151	CDD:320454	10/25 (40%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	8/21 (38%)
		TM helix 5	247..276	CDD:320454	11/28 (39%)
		7tm_GPCRs	<525..599	CDD:475119	32/73 (44%)
		TM helix 6	533..555	CDD:410628	11/21 (52%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	70/196 (36%)
adra1bb	NP_001007359.1	7tm_GPCRs	48..359	CDD:475119	119/508 (23%)
		TM helix 1	50..74	CDD:410628	9/23 (39%)
		TM helix 2	83..105	CDD:410628	9/21 (43%)
		TM helix 3	121..143	CDD:410628	13/21 (62%)
		TM helix 4	166..182	CDD:410628	5/15 (33%)
		TM helix 5	203..226	CDD:410628	9/22 (41%)
		TM helix 6	293..315	CDD:410628	11/21 (52%)
		TM helix 7	327..352	CDD:410628	14/24 (58%)