Protein Alignment 5-HT1B and Dop1R2

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 169/599 - (28%)
• Similarity: 237/599 - (39%)
• Gaps: 182/599 - (30%)

  Fly    30 LNESLFIELNG--NLTQLV--DTTSNLSQIVWNRSI-NGNGNSNTFDLVDDEQERAAVEFW--LL 87
            ::|.::...||  ..|:||  .|||..|..:....: .|.|.:.|       .|....||.  |.
  Fly    48 ISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTT-------PEPDLSEFLEALP 105

  Fly    88 VKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEI 152
            ...:.:...|.|....|:.||..||.|:|.||.|....||.:.||||||..|..:|||..|:||:
  Fly   106 NDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEV 170

  Fly   153 -SNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWF 215
             .|.|..|.:.||||.|.|||..|||||:|..|:.||||.:|: ..|....|.:|...:|..||.
  Fly   171 LENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWI 235

  Fly   216 AALIVSLAPQFGWKD------PDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIY 274
            .:..:|......|:.      |.|       .|..::.:||.:|::..:||:||||::|.|.:||
  Fly   236 CSSAISFPAIVWWRAARDGEMPAY-------KCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIY 293

  Fly   275 IIARKRIQRRAQK---------SFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGD 330
            ..|  .||.|:.|         |..:.||                 .|..|......::..|.|.
  Fly   294 RAA--VIQTRSLKIGTKQVLMASGELQLT-----------------LRIHRGGTTRDQQNQVSGG 339

  Fly   331 GTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDN 395
            |.||              |..       .|..|:::.|                   .|.|::.:
  Fly   340 GGGG--------------GGG-------GGGGGSLSHS-------------------HSHSHHHH 364

  Fly   396 KSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLT 460
            .:|.|...|:...:.||                     ..|.|.|.|.   ||:...|
  Fly   365 HNHGGGTTTSTPEEPDD---------------------EPLSALHNNG---LARHRHM------- 398

  Fly   461 TTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLE 525
                                               |||..:.                  |:|.:
  Fly   399 -----------------------------------GKNFSLS------------------RKLAK 410

  Fly   526 AKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVAS-LFLWLGYFNSTLNPVIYT 589
            ..:|:|||:||.|:.|.|:||||||||:.|....|.||..|..:.| :..|||:.||.:|||||.
  Fly   411 FAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYA 475

  Fly   590 IFNPEFRRAFKRIL 603
            .::.:|||||.|:|
  Fly   476 CWSRDFRRAFVRLL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/25 (36%)
		TM helix 2	125..151	CDD:320454	13/25 (52%)
		TM helix 3	163..193	CDD:320454	19/29 (66%)
		TM helix 4	204..226	CDD:320454	5/21 (24%)
		TM helix 5	247..276	CDD:320454	13/28 (46%)
		7tm_GPCRs	<525..599	CDD:475119	36/74 (49%)
		TM helix 6	533..555	CDD:410628	14/21 (67%)
		TM helix 7	567..592	CDD:410628	11/25 (44%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	78/203 (38%)
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	146/512 (29%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	19/29 (66%)
		TM helix 4	224..246	CDD:320195	5/21 (24%)
		TM helix 5	266..295	CDD:320195	13/28 (46%)
		TM helix 6	297..442	CDD:320195	55/285 (19%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)