DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1B and Oct-TyrR

DIOPT Version :9

Sequence 1:	NP_001137708.2	Gene:	5-HT1B / 37191	FlyBaseID:	FBgn0263116	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001163494.1	Gene:	Oct-TyrR / 42452	FlyBaseID:	FBgn0004514	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	178/567 - (31%)
Similarity:	266/567 - (46%)	Gaps:	115/567 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 AVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMP 145
            ||..|   :.:..|:||.::|::|||||:.||.::...:.|:.|.|:.:.|||||||.||.||:|
  Fly   103 AVPEW---EALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLP 164

  Fly   146 LGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLM 209
            ....|.|...|..|..||.:|.:|||||||:|||:|.|||.||||.:|: |:|...||..||.|:
  Fly   165 FNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLL 229

  Fly   210 IFCVWFAALIVSLAPQFGWKD-PDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKI 273
            |..||..:|::|..|..||.| ||  :......|.::...||.|:::..:|::||.::..:|.:|
  Fly   230 ISGVWLLSLLISSPPLIGWNDWPD--EFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEI 292

  Fly   274 YIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQR 338
            ::..|:|::.||:.:...|:.                        |::.|..|:
  Fly   293 FVATRRRLRERARANKLNTIA------------------------LKSTELEPM----------- 322

  Fly   339 RTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSH---AG 400
                         .|::.|.|.:.|:.:|.:|      :.|...|:..:|:|....|...   :.
  Fly   323 -------------ANSSPVAASNSGSKSRLLA------SWLCCGRDRAQFATPMIQNDQESISSE 368

  Fly   401 TELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSI----AMGGVGCLTT 461
            |.....||.|..:..|:..:            ||.::....:.......||    ..||....::
  Fly   369 THQPQDSSKAGPHGNSDPQQ------------QHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSS 421

  Fly   462 TT---PSEKALSGAGTVAGAV-AGGSGSGSGEEGA--GTEGKNAGVGL----------------- 503
            :|   ..|:.|..||...|:. .||..||.|:..|  .||..:...|.
  Fly   422 STCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLT 486

  Fly   504 -----GGVLASIANPHQK-------LAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALT 556
                 .||.|....|.||       ..:.:|.:...:||:||:||.||.|.|||||||||:|.:.
  Fly   487 PPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVI 551

  Fly   557 MSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            :..|:.|.......:...||||.||.||||||||||.::||||||:|
  Fly   552 LPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	76/182 (42%)
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	64/130 (49%)
Oct-TyrR	NP_001163494.1	7tm_1	126..>293	CDD:278431	71/168 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCYC
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2699
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.760