DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and Dop1R1

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001262563.1 Gene:Dop1R1 / 41726 FlyBaseID:FBgn0011582 Length:560 Species:Drosophila melanogaster


Alignment Length:644 Identity:149/644 - (23%)
Similarity:231/644 - (35%) Gaps:255/644 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 AMAAGDDDVPASIL-----EIELPAILLNESLFIELNGNLTQ----------LVD--------TT 49
            |:|||...|.|::.     .|.....::|.|....:.||.|.          |:|        ||
  Fly    10 AIAAGVGSVAATVATSTTSSISSSTTIINTSSATTIGGNHTSGSTGFSTNSTLLDADHLPLQLTT 74

  Fly    50 SNLS-QIVWNRSINGNG----------------NSNTFD-LVDDEQERAAVEFWLLVKMIAMAVV 96
            :.:. .|..:..:..||                |::..| :|.:|.|..:     ||.::.:.:.
  Fly    75 AKVDLDIEIDIQLLTNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLS-----LVSIVVVGIF 134

  Fly    97 LGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPE 161
            |.::|.:::.||:.|..||..||:|:.:.|..:||||:||||||.|||....|.::...||.|.:
  Fly   135 LSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQ 199

  Fly   162 LCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAP- 224
            .||.|.:.||:|.|||||:|.||:.|||..:.: :.|....|.|...:.|..:|..|..||..| 
  Fly   200 FCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPI 264

  Fly   225 QFGWKDPDYMKRIEEQ-----HCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRR 284
            ..|...||.....|:.     .|.:.....|.:.::|.:||.|.:|::.:|.::|..|:|.:   
  Fly   265 SLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHV--- 326

  Fly   285 AQKSFNVTLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFG 349
              ||........:    |.|.::.:|.||.:.:                       .|:.::   
  Fly   327 --KSIKAVTRPGE----VAEKQRYKSIRRPKNQ-----------------------PKKFKV--- 359

  Fly   350 RNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYR 414
            ||.:|                                                            
  Fly   360 RNLHT------------------------------------------------------------ 364

  Fly   415 TSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAV 479
                           |::.:| ::.|                                       
  Fly   365 ---------------HSSPYH-VSDH--------------------------------------- 374

  Fly   480 AGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFV 544
                                                               |||.|:.:|.|.|:
  Fly   375 ---------------------------------------------------KAAVTVGVIMGVFL 388

  Fly   545 ICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            |||:|||.:.:|.:.||.| |......:..||||.||..||:||:|||.|||.||||||
  Fly   389 ICWVPFFCVNITAAFCKTC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 7/25 (28%)
TM helix 2 125..151 CDD:320454 15/25 (60%)
TM helix 3 163..193 CDD:320454 17/29 (59%)
TM helix 4 204..226 CDD:320454 7/22 (32%)
TM helix 5 247..276 CDD:320454 8/28 (29%)
7tm_GPCRs <525..599 CDD:475119 34/73 (47%)
TM helix 6 533..555 CDD:410628 11/21 (52%)
TM helix 7 567..592 CDD:410628 11/24 (46%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 69/202 (34%)
Dop1R1NP_001262563.1 7tmA_Ap5-HTB1-like 130..442 CDD:320193 117/513 (23%)
TM helix 1 130..156 CDD:320193 7/25 (28%)
TM helix 2 163..189 CDD:320193 15/25 (60%)
TM helix 3 201..231 CDD:320193 17/29 (59%)
TM helix 4 243..265 CDD:320193 7/21 (33%)
TM helix 5 292..321 CDD:320193 8/28 (29%)
TM helix 6 371..401 CDD:320193 14/119 (12%)
TM helix 7 410..435 CDD:320193 11/24 (46%)

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