Protein Alignment 5-HT1B and Octbeta2R

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 615
• Identity: 145/615 - (23%)
• Similarity: 217/615 - (35%)
• Gaps: 221/615 - (35%)

  Fly     1 MLKTVTTAMAAGDDDVP-ASILEIELPAILLNESLFIELNGNLTQLVDTTSNLSQIVWNRSINGN 64
            ||.|.....|.|..... :|...|.||                  |...|....::...:...|:
  Fly    75 MLHTTNALAATGSSSASNSSTGGIALP------------------LGTATPATHELNATQPFGGS 121

  Fly    65 G---NSNTFDLVD--DEQERAAVEFWL-LVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQN 123
            |   |.:...|.|  ..|:....|.|| .:..:..|.|:.|:|:..|.||:.||.:::..|.|:.
  Fly   122 GLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRV 186

  Fly   124 VANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADR 188
            :.||.|.|||:||:.||.:.|......:::..|...|.|||:|.|.||...|||||||..|:.||
  Fly   187 ITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDR 251

  Fly   189 YWTVTN-IDYNNLRTPRRVFLMIFCVWFAALIVSLAPQF-GW-KDPDYMKRIEEQ--HCMVSQDV 248
            |:.:.. :.|....|.|.|.:|:...|.:..::|..|.| || ..|.:.:.:.:.  .|....:.
  Fly   252 YYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNK 316

  Fly   249 GYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRR 313
            .|.:.::..:|::|..:::|.|
  Fly   317 YYAVISSSISFWIPCTIMIFTY------------------------------------------- 338

  Fly   314 AERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFAS 378
                                                                             
  Fly   339 ----------------------------------------------------------------- 338

  Fly   379 LAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNA 443
            |||.||                                            |:..:..|:..|.||
  Fly   339 LAIFRE--------------------------------------------ANRQEKQLMMRHGNA 359

  Fly   444 ITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLA 508
            :.....|:           .||.:||||:|:                     .|..      .|.
  Fly   360 MLMHRPSM-----------QPSGEALSGSGS---------------------SKTL------TLH 386

  Fly   509 SIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLF 573
            .:...|.. .|.:.|::.|||.|||:||.||.|.|::||||||:.......|:||::...|.|:.
  Fly   387 EVEQEHTP-TKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSIL 450

  Fly   574 LWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            .|:|||||||||:||..||.:||.||:..|
  Fly   451 FWIGYFNSTLNPLIYAYFNRDFREAFRNTL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	9/25 (36%)
		TM helix 2	125..151	CDD:320454	11/25 (44%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	6/21 (29%)
		TM helix 5	247..276	CDD:320454	5/28 (18%)
		7tm_GPCRs	<525..599	CDD:475119	39/73 (53%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	14/24 (58%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	60/200 (30%)
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	122/511 (24%)
		TM helix 1	155..181	CDD:320194	9/25 (36%)
		TM helix 2	188..214	CDD:320194	11/25 (44%)
		TM helix 3	226..256	CDD:320194	17/29 (59%)
		TM helix 4	268..291	CDD:320194	6/22 (27%)
		TM helix 5	315..344	CDD:320194	8/136 (6%)
		TM helix 6	404..434	CDD:320194	18/29 (62%)
		TM helix 7	444..469	CDD:320194	14/24 (58%)