Protein Alignment 5-HT1B and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 888
• Identity: 201/888 - (22%)
• Similarity: 291/888 - (32%)
• Gaps: 348/888 - (39%)

  Fly    48 TTSN-------LSQIVWNRSINGNGN-SNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVT 104
            ||:|       |....||.:  ||.. |.||:.|..:    |..:|.|   :|:.:|||     |
  Fly    37 TTANATSRHNQLHVARWNAT--GNATISATFEDVPFD----ANNYWAL---LALVLVLG-----T 87

  Fly   105 IIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSC 169
            ..||:.|..||..||.||||.||.:.|||:.||.||.||||||.:..:...:.||.|.|..|...
  Fly    88 AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICL 152

  Fly   170 DVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDY 233
            |||.|||||:||..|:.|||.::. .:.:...:|.|||.|.|..||..::.:|| |.......::
  Fly   153 DVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL-PLSLMYSKNH 216

  Fly   234 MKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLY-WKIYIIARKR----------------- 280
            ...:....|.:...| |::..:...||:||.|:|..| ..:.::||:|
  Fly   217 ASVLVNGTCQIPDPV-YKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWA 280

  Fly   281 ---------IQRRAQ----------------KSFNVTLTETDC-----------DSAVRE----- 304
                     ::||..                .:.:...|:||.           ||:::|
  Fly   281 SGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTT 345

  Fly   305 -----------LKKERS------------------------------------------------ 310
                       ||..|.
  Fly   346 MTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQ 410

  Fly   311 -------------------------------KRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRM 344
                                           :|.:.|..|.:........|||..||.:|.|
  Fly   411 QHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLR--- 472

  Fly   345 RICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSD 409
              .:.:....::.|.|.|.......|...|:..:..:.|.:...|..    |:......|||...
  Fly   473 --AYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLP----KNALYPRHTTVQES 531

  Fly   410 ADDYRTSNANEIITLSQQ----VAH----------ATQHHLIASH-------------------- 440
            .||.............||    :.|          |.|.|:...:
  Fly   532 LDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDR 596

  Fly   441 --LNAITPLAQSIAMGGVGCLTTTT-----PSEKAL----SG-----AGTVAGAVAGG------- 482
              .|.:......|........||||     |||..|    ||     ..:|:..:.||
  Fly   597 PLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPA 661

  Fly   483 -------------SGS-------GSGEEGA-GT----------------------EGKNAGVGLG 504
                         .||       |||...| ||                      ..:..|...|
  Fly   662 TVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFG 726

  Fly   505 GVLASI-------------ANP---------HQK---------------------LAKRRQLLEA 526
            ||..|:             :.|         ||.                     :.:|:|.:.:
  Fly   727 GVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRS 791

  Fly   527 --------------------KRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECE--IHTAV 569
                                :.|:||.:.|.::...|||.|.||||:.|..::|.|||  |...|
  Fly   792 HHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWV 856

  Fly   570 ASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAAARA 612
            ..:..||||.:|.:||:.|||||..||:|||::|..|.::..|
  Fly   857 FDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSA 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/25 (40%)
		TM helix 2	125..151	CDD:320454	15/25 (60%)
		TM helix 3	163..193	CDD:320454	16/29 (55%)
		TM helix 4	204..226	CDD:320454	10/21 (48%)
		TM helix 5	247..276	CDD:320454	9/29 (31%)
		7tm_GPCRs	<525..599	CDD:475119	33/95 (35%)
		TM helix 6	533..555	CDD:410628	9/21 (43%)
		TM helix 7	567..592	CDD:410628	11/24 (46%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	76/239 (32%)
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	76/202 (38%)
		TM helix 1	75..101	CDD:320433	12/33 (36%)
		TM helix 2	108..134	CDD:320433	15/25 (60%)
		TM helix 3	146..176	CDD:320433	16/29 (55%)
		TM helix 4	188..211	CDD:320433	10/23 (43%)
		TM helix 5	229..258	CDD:320433	9/29 (31%)
		7tm_GPCRs	<799..893	CDD:475119	37/93 (40%)
		TM helix 6	818..840	CDD:410628	9/21 (43%)
		TM helix 7	854..879	CDD:410628	11/24 (46%)