DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT1B and mAChR-A

DIOPT Version :10

Sequence 1:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_523844.2 Gene:mAChR-A / 37892 FlyBaseID:FBgn0000037 Length:805 Species:Drosophila melanogaster


Alignment Length:809 Identity:196/809 - (24%)
Similarity:293/809 - (36%) Gaps:270/809 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 TVTTAMAAGDDDVPASILEIELPAILLNESLFIELNGNLTQ-LVDTTSNLSQIVWNRSINGNGNS 67
            |.|||..||..  |.      .|...|..:||..|...... |.|..|.:         .||..:
  Fly    40 TTTTASPAGYS--PG------YPGTTLLTALFENLTSTAASGLYDPYSGM---------YGNQTN 87

  Fly    68 NTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASL 132
            .|... :.:..|     :.|..|:.|..|..::..||:.|||.|:.:..:::.||.::||.:.||
  Fly    88 GTIGF-ETKGPR-----YSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSL 146

  Fly   133 AVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-ID 196
            |:||..:..:.|||.||..|...|.|||.:||.|.:.|.|...||:|:|:.|:.|||::||. :.
  Fly   147 AIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLT 211

  Fly   197 YNNLRTPRRVFLMIFCVWFAALIVSLAPQFGW----------KDPDYMKRIEEQHCMVSQDVGYQ 251
            |...||..|..:||...|..:|::.....:.|          ||..|::.||...        |.
  Fly   212 YRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQ--------YI 268

  Fly   252 IFATC-CTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAE 315
            .|.|. ..||.|:.::.||||:|:...:||     ||                :|...::.::..
  Fly   269 TFGTALAAFYFPVTIMCFLYWRIWRETKKR-----QK----------------DLPNLQAGKKDS 312

  Fly   316 RKRLEAGERTPVDGDGTGGQLQ------------RRTRK------------RMRICFG------- 349
            .||..:.:...|....:||.|.            ||.|.            .|.|..|       
  Fly   313 SKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSR 377

  Fly   350 ----RNTNT---ANVVAGS--EGAVA--RSMAAIAVDFASLAITREETEFSTSNY---------- 393
                ::|||   :....||  |..:|  .|....:.|||     .|:.|.|...|          
  Fly   378 KSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFA-----YEQEEPSDLGYATPVTIETPL 437

  Fly   394 --------------DNKSHAGT---------------------------------ELTTVSSDAD 411
                          ||.|..|:                                 ...|.|:.|:
  Fly   438 QSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTAN 502

  Fly   412 DYRTSNANEIITLSQQVAH-------------------ATQHHLIASHLNAIT-PL-----AQSI 451
            ...:.|.|..|..:...:|                   .|..:  |:|.::.| |:     ::|:
  Fly   503 VNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGN--ATHRDSRTLPVINRINSRSV 565

  Fly   452 AMGGVGCLTTTTPSEKALS------GAGTVAGAVAGGSGSGSG----------EEGAGTE----- 495
            :...|..:....||:.|.|      |.|..|||.|..|.|..|          |:|..|.     
  Fly   566 SQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAP 630

  Fly   496 -------------------------------------------------GKNAGVGLGGVLASIA 511
                                                             |..||.|:||..| :.
  Fly   631 LASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHA-LM 694

  Fly   512 NPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMAL--TMSLCKECEIHTAVASLFL 574
            |......|:::..|.::|.|||:||:.|..:|:|.|.|:.::.|  .::.|.:| |.|.:...|.
  Fly   695 NARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDC-IPTELWDFFY 758

  Fly   575 WLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            .|.|.|||:||:.|.:.|..|||.:.|||
  Fly   759 ALCYINSTINPMCYALCNATFRRTYVRIL 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 8/25 (32%)
TM helix 2 125..151 CDD:320454 12/25 (48%)
TM helix 3 163..193 CDD:320454 13/29 (45%)
TM helix 4 204..226 CDD:320454 5/21 (24%)
TM helix 5 247..276 CDD:320454 11/29 (38%)
7tm_GPCRs <525..599 CDD:475119 30/75 (40%)
TM helix 6 533..555 CDD:410628 8/21 (38%)
TM helix 7 567..592 CDD:410628 10/24 (42%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 69/207 (33%)
mAChR-ANP_523844.2 7tmA_mAChR_DM1-like 105..>300 CDD:320428 69/207 (33%)
TM helix 1 106..132 CDD:320428 8/25 (32%)
TM helix 2 139..165 CDD:320428 12/25 (48%)
TM helix 3 177..207 CDD:320428 13/29 (45%)
TM helix 4 219..242 CDD:320428 5/22 (23%)
TM helix 5 265..294 CDD:320428 11/36 (31%)
7tm_GPCRs <707..783 CDD:475119 30/76 (39%)
TM helix 6 716..738 CDD:410628 8/21 (38%)
TM helix 7 751..776 CDD:410628 10/24 (42%)

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