DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT1B and mAChR-A

DIOPT Version :9

Sequence 1:	NP_001137708.2	Gene:	5-HT1B / 37191	FlyBaseID:	FBgn0263116	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	196/809 - (24%)
Similarity:	293/809 - (36%)	Gaps:	270/809 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVTTAMAAGDDDVPASILEIELPAILLNESLFIELNGNLTQ-LVDTTSNLSQIVWNRSINGNGNS 67
            |.|||..||..  |.      .|...|..:||..|...... |.|..|.:         .||..:
  Fly    40 TTTTASPAGYS--PG------YPGTTLLTALFENLTSTAASGLYDPYSGM---------YGNQTN 87

  Fly    68 NTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASL 132
            .|... :.:..|     :.|..|:.|..|..::..||:.|||.|:.:..:::.||.::||.:.||
  Fly    88 GTIGF-ETKGPR-----YSLASMVVMGFVAAILSTVTVAGNVMVMISFKIDKQLQTISNYFLFSL 146

  Fly   133 AVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-ID 196
            |:||..:..:.|||.||..|...|.|||.:||.|.:.|.|...||:|:|:.|:.|||::||. :.
  Fly   147 AIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLT 211

  Fly   197 YNNLRTPRRVFLMIFCVWFAALIVSLAPQFGW----------KDPDYMKRIEEQHCMVSQDVGYQ 251
            |...||..|..:||...|..:|::.....:.|          ||..|::.||...        |.
  Fly   212 YRAKRTTNRAAVMIGAAWGISLLLWPPWIYSWPYIEGKRTVPKDECYIQFIETNQ--------YI 268

  Fly   252 IFATC-CTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTETDCDSAVRELKKERSKRRAE 315
            .|.|. ..||.|:.::.||||:|:...:||     ||                :|...::.::..
  Fly   269 TFGTALAAFYFPVTIMCFLYWRIWRETKKR-----QK----------------DLPNLQAGKKDS 312

  Fly   316 RKRLEAGERTPVDGDGTGGQLQ------------RRTRK------------RMRICFG------- 349
            .||..:.:...|....:||.|.            ||.|.            .|.|..|
  Fly   313 SKRSNSSDENTVVNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSR 377

  Fly   350 ----RNTNT---ANVVAGS--EGAVA--RSMAAIAVDFASLAITREETEFSTSNY---------- 393
                ::|||   :....||  |..:|  .|....:.|||     .|:.|.|...|
  Fly   378 KSSIKSTNTIKKSYTCFGSIKEWCIAWWHSGREDSDDFA-----YEQEEPSDLGYATPVTIETPL 437

  Fly   394 --------------DNKSHAGT---------------------------------ELTTVSSDAD 411
                          ||.|..|:                                 ...|.|:.|:
  Fly   438 QSSVSRCTSMNVMRDNYSMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTAN 502

  Fly   412 DYRTSNANEIITLSQQVAH-------------------ATQHHLIASHLNAIT-PL-----AQSI 451
            ...:.|.|..|..:...:|                   .|..:  |:|.::.| |:     ::|:
  Fly   503 VNTSGNGNGAINNNNNASHNGNGAVNGNGAGNGSGIGLGTTGN--ATHRDSRTLPVINRINSRSV 565

  Fly   452 AMGGVGCLTTTTPSEKALS------GAGTVAGAVAGGSGSGSG----------EEGAGTE----- 495
            :...|..:....||:.|.|      |.|..|||.|..|.|..|          |:|..|.
  Fly   566 SQDSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAP 630

  Fly   496 -------------------------------------------------GKNAGVGLGGVLASIA 511
                                                             |..||.|:||..| :.
  Fly   631 LASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHA-LM 694

  Fly   512 NPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFVMAL--TMSLCKECEIHTAVASLFL 574
            |......|:::..|.::|.|||:||:.|..:|:|.|.|:.::.|  .::.|.:| |.|.:...|.
  Fly   695 NARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDC-IPTELWDFFY 758

  Fly   575 WLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603
            .|.|.|||:||:.|.:.|..|||.:.|||
  Fly   759 ALCYINSTINPMCYALCNATFRRTYVRIL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	66/192 (34%)
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	48/123 (39%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	68/221 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010