Protein Alignment 5-HT1B and drd2b

DIOPT Version :10

• Sequence 1: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_922918.1
• Gene: drd2b / 378719
• ZFINID: ZDB-GENE-030910-2
• Length: 452
• Species: Danio rerio
• Alignment Length: 526
• Identity: 144/526 - (27%)
• Similarity: 224/526 - (42%)
• Gaps: 127/526 - (24%)

  Fly    94 AVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWIL 158
            |::|.|:|.|.:.|||.|..|:..|:.||...|||:.|||||||.||.||||.....|:...|..
Zfish    36 AMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRF 100

  Fly   159 GPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTNIDYNNLR--TPRRVFLMIFCVWFAALIVS 221
            ....|||:.:.||:.||||||:|.||:.|||..|......|.|  :.|||.:||..||..:..:|
Zfish   101 SKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAIS 165

  Fly   222 LAPQFGWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQ 286
            ....||..:   ....:...|.:: :..:.::::..:||||.::.|.:|.:||::.||| ::|..
Zfish   166 CPLLFGLNN---TATRDGSVCEIA-NPAFVVYSSIMSFYVPFIITLLVYVQIYVVLRKR-RKRVN 225

  Fly   287 KSFNVTLTETDCDSAVRE-------------LKKERSKRRAERKRLEAGERTPVDGDGTGGQLQR 338
            ...:...|:.|....::|             :.|......|:.|:.:..:.....|...|.::
Zfish   226 TKRSCQKTDADAQPPLKEKCTHPEDVKLCTVIIKTNGGVPAKNKKAQLIKEVLHQGGDVGMEM-- 288

  Fly   339 RTRKRMRICFGRNTNTANVVAGSEGAVARSMA-AIAVDFASLAITREETEFSTSNYDNKSHAGTE 402
                               |||:.....:.:| ::.||..:..        .:.|:.:.|||
Zfish   289 -------------------VAGTSPPEKKKLASSLVVDLLATP--------PSPNHGSPSHA--- 323

  Fly   403 LTTVSSDADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEK 467
                     :|: ||.:|      :..||..   :.|.........|::..|......|.|.|::
Zfish   324 ---------EYQ-SNGDE------KNGHAKD---VQSPKETKPVETQALPNGKTRTTVTKTMSKR 369

  Fly   468 ALSGAGTVAGAVAGGSGSGSGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKA 532
            .:|                                                       ..:|:||
Zfish   370 KMS-------------------------------------------------------QHKEKKA 379

  Fly   533 AQTLAIITGAFVICWLPFFVMALTMSLCKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRR 597
            .|.|||:.|.|:|||||||:..:..:.|..|.:...:.:.|.||||.||.:||:|||.||.|||:
Zfish   380 TQMLAIVLGVFIICWLPFFITHILKTHCTSCVVPLEMYNAFTWLGYVNSAVNPIIYTTFNVEFRK 444

  Fly   598 AFKRIL 603
            ||.:||
Zfish   445 AFIKIL 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT1B	NP_001137708.2	TM helix 1	92..118	CDD:320454	10/23 (43%)
		TM helix 2	125..151	CDD:320454	16/25 (64%)
		TM helix 3	163..193	CDD:320454	17/29 (59%)
		TM helix 4	204..226	CDD:320454	8/21 (38%)
		TM helix 5	247..276	CDD:320454	8/28 (29%)
		7tm_GPCRs	<525..599	CDD:475119	35/73 (48%)
		TM helix 6	533..555	CDD:410628	13/21 (62%)
		TM helix 7	567..592	CDD:410628	12/24 (50%)
		7tmA_5-HT1A_invertebrates	91..>287	CDD:320454	74/194 (38%)
drd2b	NP_922918.1	7tm_GPCRs	33..446	CDD:475119	140/520 (27%)
		TM helix 1	35..59	CDD:410628	10/22 (45%)
		TM helix 2	68..90	CDD:410628	16/21 (76%)
		TM helix 3	106..128	CDD:410628	13/21 (62%)
		TM helix 4	152..168	CDD:410628	5/15 (33%)
		TM helix 5	188..211	CDD:410628	5/22 (23%)
		TM helix 6	380..402	CDD:410628	13/21 (62%)
		TM helix 7	414..439	CDD:410628	12/24 (50%)